ilvmНормативно-правовое регулирование в ветеринарииLegal regulation in veterinary medicine2782-6252SpbGUVM Publishing House10.52419/issn2782-6252.2026.2.80ilvm-1082Research ArticleРЕЗУЛЬТАТЫ НАУЧНЫХ ИССЛЕДОВАНИЙ В ВЕТЕРИНАРИИ. ИНФЕКЦИОННЫЕ БОЛЕЗНИRESULTS OF SCIENTIFIC RESEARCH IN VETERINARY MEDICINE: INFECTIOUS DISEASESПрактическое значение измерения концентрации цитокинов при бронхопневмонии телятPractical value of measuring cytokine concentration in calf bronchopneumoniahttps://orcid.org/0009-0006-9374-8545СтепановаН. А.StepanovaN. A.

Наталья Алексеевна Степанова - аспирант каф. микробиологии, вирусологии и иммунологии 

Natalia Al. Stepanova - Postgraduate Student, Department of Microbiology, Virology, and Immunology

nas2001@list.ruСухининА. А.SukhininA. A.

Александр Александрович Сухинин - д-р биол. наук, проф., заведующий кафедрой микробиологии, вирусологии и иммунологии 

Aleksandr Al. Sukhinin - Doctor of Biological Sciences, Professor, Head of the Department of Microbiology, Virology, and Immunology

Санкт-Петербургский государственный университет ветеринарной медициныРоссияSaint Petersburg State University of Veterinary MedicineRussian Federation202614082026028085Copyright © Степанова Н.А., Сухинин А.А., 20262026Степанова Н.А., Сухинин А.А.Stepanova N.A., Sukhinin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ilvm.elpub.ru/jour/article/view/1082

Поражение респираторного тракта телят по своей распространенности занимают второе место среди болезней молодняка крупного рогатого скота. Интересующая нас бронхопневмония телят наносит значительный экономический ущерб хозяйствам. Согласно имеющимся литературным данным одним из важных прогностических аспектов возникновения и развития данной патологии служит измерение концентрации цитокинов в крови телят, которое успешно внедрено в рутинную практику зарубежных ветеринарных специалистов. Целью работы стало обобщение имеющихся данных о роли цитокинов в патогенезе бронхопневмонии телят, а также обоснование необходимости исследования цитокинового профиля не только в научных исследованиях, но и в практике ветеринарных врачей. На основании проанализированных литературных источников мы выделяем следующие изменений цитокинового профиля крови у больных телят: снижение концентрации ИЛ-1A и повышение уровня ИЛ-1β, ИЛ-6, ИЛ-8; при отборе проб с помощью бронхоальвеолярного лаважа повышение концентрации ФНО-α и ИФН-γ; при переходе воспалительного процесса в альвеолярную ткань лёгких повышение ИЛ-12, ИЛ-6, ФНО-α и ИФН-γ.

Lesions of the respiratory tract of calves in their prevalence rank second among diseases of young cattle. The bronchopneumonia of calves that interests us causes significant economic damage to farms. According to the available literature, one of the important prognostic aspects of the emergence and development of this pathology is the measurement of the concentration of cytokines in the blood of calves, which successfully introduced into the routine practice of foreign veterinary specialists. The aim of the work was to summarize the available data on the role of cytokines in the pathogenesis of calf bronchopneumonia, as well as to justify the need to study the cytokine profile not only in scientific research, but also in the practice of veterinary doctors. Based on the analyzed literature we identify the following changes in the cytokine profile of blood in sick calves: a decrease in the concentration of IL-1A and an increase in the level of IL-1β, IL-6, IL-8; during sampling using bronchoalveolar lavage, an increase in the concentration of TNF- α and IFN- γ; during the transition of the inflammatory process into the alveolar tissue of the lungs, an increase in IL-12, IL-6, TNF- α and IFN- γ.

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The authors declare that there are no conflicts of interest present.