The article describes the results of studies on the content of total protein, urea and creatinine in the blood serum of female sheep and pigs in postnatal ontogenesis, living in the area of iodocyte. As a result of researches it is established that reliable distinctions on level of the General protein in blood serum of sheep are revealed between 9 and 12-month animals, at 12-month females it was lower on 5%. The analysis of data on the level of total protein in the blood of pigs revealed significant differences in the parameters of this indicator between the previous and subsequent groups. Its lowest values are recorded in newborn animals - 47,5±4,15 g/l. In the study of urea content, significant differences were found in sheep between newborns and 3-month, and 9 and 12-month, and in pigs - in 3 and 6-month age. The level of creatinine in sheep significantly changed only at 6 months of age, which is 8.3% (p≤0.05) lower compared to 3-month-old lambs. In pigs, the value of this indicator in the sixth month of life was higher by 39.5% (p≤0.05), compared with the previous age period. Also in pigs there was a significant decrease in creatinine level in 12 months, compared with 9 months by 45.7% (p≤0.05). Thus, the data obtained can be used as a constant for sheep and pigs bred in the area of iodine deficiency, which is the Stavropol territory.