The article presents data on the characteristics of the biochemical profile in cows with inflammatory diseases of the udder. The study of biochemical blood parameters in highly productive cows with the inflammation of the mammary gland showed an increase in the average content of total protein to 84,6±0.9 g/l, the increase in the number of globulins more than 45,0 g/l was observed in 76.9% of the cows. Also diagnosed with increase in the level of triglycerides in 73,1% of the animals. The increase in cholesterol over 5.0 mmol/l was observed in 19.2% of the cows. The average value of potassium concentration was 2.4±0.3 mmol/l, which is 1.7 times below the physiological norm. 16.3 per cent of the animals showed a decrease in sodium concentration below 130 mmol/l showed a reduction in concentration of bicarbonate less than 21 mmol/l at 9.1%, chloride less than 96 mmol/l in 18.2% of cows, respectively. The average content of zinc in the blood amounted to 20.9±1.2 pmol/l, while in 18.2% of the cows this figure was below the physiological norm. From 50,0% of the animals in the blood diagnosed by the reduction of magnesium less than 0.7 mmol/L. Have for 90.9% of the studied animals have been discovered increasing the concentration of copper in the blood, while the average copper concentration of 25.7±1.1 pmol/l, which is 1.4 times above the linguistic standards. The amount of calcium and phosphorus were within the physiological norm and amounted to an average of 2.1±0.1 mmol/l and 1.5±0.1 mmol/l, respectively, a slight deviation to the downside of these parameters was observed in 18.2% and 36.4% of the animals.