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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ilvm</journal-id><journal-title-group><journal-title xml:lang="ru">Нормативно-правовое регулирование в ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>Legal regulation in veterinary medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2782-6252</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52419/issn2782-6252.2022.4.87</article-id><article-id custom-type="elpub" pub-id-type="custom">ilvm-465</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕЗАРАЗНЫЕ БОЛЕЗНИ</subject></subj-group></article-categories><title-group><article-title>Профилактика субклинических форм гипокальцемии и кетоза молочных коров</article-title><trans-title-group xml:lang="en"><trans-title>Prevention of subclinical forms of hypocalcemia and ketosis in dairy cows</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенов</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenov</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р.биол.наук, проф.</p></bio><bio xml:lang="en"><p>Dr. Habil. of Biological Sciences, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюрин</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyurin</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р.ветеринар.наук, проф.</p></bio><bio xml:lang="en"><p>Dr. Habil. of Veterinary Sciences, Prof</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецов</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsov</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р.ветеринар.наук, проф.</p></bio><bio xml:lang="en"><p>Dr. Habil. of Veterinary Sciences, Prof</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симурзина</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Simurzina</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд.ветеринар.наук, доц.</p></bio><bio xml:lang="en"><p>PhD of Veterinary Sciences, Docent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитин</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitin</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р.ветеринар.наук, доц.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондручина</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondruchina</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд.ветеринар.наук, доц.</p></bio><bio xml:lang="en"><p>PhD of Veterinary Sciences, Docent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитин</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitin</surname><given-names>G. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд.ветеринар.наук, доц.</p></bio><bio xml:lang="en"><p>PhD of Veterinary Sciences, Docent</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Чувашский государственный аграрный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chuvash State Agrarian University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ВНИИВСГЭ – филиал ФГБНУ ФНЦ ВИЭВ РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>VNIIVSGE - branch of the Federal State Budgetary Scientific Institution FNTs VIEV RAS</institution><country>Russian Federation</country></aff></aff-alternatives><aff xml:lang="ru" id="aff-3"><institution>Санкт-Петербургский государственный университет ветеринарной медицины</institution><country>Russian Federation</country></aff><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет ветеринарной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University of Veterinary Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>06</day><month>01</month><year>2023</year></pub-date><volume>0</volume><issue>4</issue><fpage>87</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Семенов В.Г., Тюрин В.Г., Кузнецов А.Ф., Симурзина Е.П., Никитин Д.А., Кондручина С.Г., Никитин Г.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Семенов В.Г., Тюрин В.Г., Кузнецов А.Ф., Симурзина Е.П., Никитин Д.А., Кондручина С.Г., Никитин Г.С.</copyright-holder><copyright-holder xml:lang="en">Semenov V.G., Tyurin V.G., Kuznetsov A.F., Simurzina E.P., Nikitin D.A., Kondruchina S.G., Nikitin G.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ilvm.elpub.ru/jour/article/view/465">https://ilvm.elpub.ru/jour/article/view/465</self-uri><abstract><p>С целью повышения молочной и мясной продуктивности крупного рогатого скота ведется активное внедрение на животноводческих предприятиях современных технологий содержания, кормления и эксплуатации. На фоне технологических стресс-факторов у крупного рогатого скота отмечается сокращение продолжительности продуктивного использования, что обусловлено высокой заболеваемостью в результате снижения иммунного ответа. Экономические потери, связанные с послеродовыми заболеваниями, вынуждают специалистов принимать более обоснованные решения относительно профилактики и терапии данной группы болезней.</p><p>Именно по этой причине целью нашего исследования стало изучение распространения послеродовых заболеваний высокопродуктивных коров и профилактика нарушений метаболизма после отела биопрепаратами PS-2, Prevention-N-E и ПДЭ с Е-селен.</p><p>В ходе анализа заболеваемости выявлено, что после отела у коров чаще всего регистрируют акушерско-гинекологические патологии: мастит (26,5%), эндометрит (24,5%), субинволюцию матки (24,15%), задержание последа (7,15%), заболевания яичников (17,45%). На фоне погрешностей в кормлении в транзитный период у животных наблюдается дефицит кальция, глюкозы, фосфора, а также превышение референсных значений по показателям обмена аминотрансфераз. После иммунокоррекции организма у животных 1-й, 2-й и 3-й опытных групп отмечается увеличение уровня кальция в отличие от контроля на 0,22 ммоль/л – PS-2, 0,27 ммоль/л – Prevention-N-E и 0,24 ммоль/л – ПДЭ+Е-селен. Аналогичная динамика наблюдалась и по уровню глюкозы в крови коров опытных групп, превосходя контрольные показатели на 22–38 %.</p><p>Применение биопрепаратов PS-2, Prevention-N-E и ПДЭ с Е-селен позволило сократить случаи субклинического кетоза и гипокальциемии у новотельных коров в два раза в сравнении с животными, которым инъекции препаратов не проводились, что свидетельствует о нормализации минерального обмена организма и усвояемости питательных веществ кормовой моносмеси. </p></abstract><trans-abstract xml:lang="en"><p>Obtaining livestock products from healthy livestock is the main goal of the entire livestock industry. The intensification of animal husbandry is accompanied by the active introduction of modern technologies for keeping, feeding and exploitation. Against the background of technological stress factors in cattle, there is a decrease in the duration of productive use, which is due to high morbidity against the background of a decrease in the immune response. The economic losses associated with postpartum illness are forcing professionals to make more informed decisions about prevention and treatment.</p><p>It is for this reason that the purpose of our study was to study the spread of postpartum diseases in highly productive cows and the prevention of metabolic disorders in newborn cows with PS-2, Prevention-N-E and PDE with E-selenium.</p><p>In the course of the analysis of morbidity, it was revealed that after calving cows, obstetric and gynecological pathologies are most often recorded: mastitis (26.5%), endometritis (24.5%), subinvolution of the uterus (24.15%), retention of the placenta (7.15%), ovarian diseases (17.45%). Against the background of inaccuracies in feeding during the transition period, the animals have a deficiency of calcium, glucose, phosphorus, as well as an excess of reference values in terms of aminotransferase metabolism. Against the background of immunocorrection of the body in cows of 1,2 and 3 experimental groups, an increase in the level of calcium, in contrast to the control, is noted by 0.22 mmol / l - PS-2, 0.27 - Prevention-NE and 0.24 mmol / l - PDE+ E-selenium. Similar dynamics was observed in the level of glucose in the blood of cows of the experimental groups, exceeding the control values by 22-38%.</p><p>The use of PS-2, Prevention-N-E and PDE with E-selenium made it possible to reduce the risk of latent ketosis and hypocalcemia by 2 times, compared with animals that did not receive prophylaxis.</p><p>The obtained results of biochemical studies prove the stimulating effect of biological products on the mineral metabolism of the body and the absorption of macronutrients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коровы</kwd><kwd>обмен веществ</kwd><kwd>кетоз</kwd><kwd>гипокальциемия</kwd><kwd>субклиническая форма</kwd><kwd>профилактика</kwd><kwd>биопрепараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cows</kwd><kwd>metabolism</kwd><kwd>ketosis</kwd><kwd>hypocalcemia</kwd><kwd>subclinical form</kwd><kwd>prevention</kwd><kwd>biological products</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Albaaj A, Jattiot M, Manciaux L et al. 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