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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ilvm</journal-id><journal-title-group><journal-title xml:lang="ru">Нормативно-правовое регулирование в ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>Legal regulation in veterinary medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2782-6252</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52419/issn2782-6252.2023.2.84</article-id><article-id custom-type="elpub" pub-id-type="custom">ilvm-575</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОЛОГИЯ, ТОКСИКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOLOGY, TOXICOLOGY</subject></subj-group></article-categories><title-group><article-title>Токсичность Этопозида в лечении кошек при лимфоме</article-title><trans-title-group xml:lang="en"><trans-title>Toxicity of Etopozid in the treatment of cats with lymphoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гурина</surname><given-names>Е. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurina</surname><given-names>E. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p></bio><bio xml:lang="en"><p>PhD Student</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4480-9488</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лунегов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lunegov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд.ветеринар.наук, доц.</p></bio><bio xml:lang="en"><p>PhD of Veterinary Sciences, Docent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет ветеринарной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University of Veterinary Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>07</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>84</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гурина Е.Р., Лунегов А.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Гурина Е.Р., Лунегов А.М.</copyright-holder><copyright-holder xml:lang="en">Gurina E.R., Lunegov A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ilvm.elpub.ru/jour/article/view/575">https://ilvm.elpub.ru/jour/article/view/575</self-uri><abstract><p>Лимфома у кошек – это злокачественное новообразование лимфоидной ткани (поражаются лимфоциты и другие клетки системы защиты). Причины возникновения лимфомы у кошек могут быть различными, включая генетический фактор, вирусы и воздействие канцерогенов. Чаще всего пациенты поступают на приём уже с запущенной стадией лимфомы, так как признаки проявления онкологического заболевания неспецифичны и их можно легко спутать с другими заболеваниями желудочнокишечного тракта. Симптомы у кошек могут включать увеличение лимфатических узлов в брюшной полости, снижение аппетита и потерю мышечной массы тела, изменение поведения (апатия, слабость), рвота, повышение температуры тела. Лимфома у кошек составляет 50-90% всех образований гемопоэтический системы. Химиотерапия является одним из основных методов лечения и заключается в применении цитостатиков, которые подавляют рост и деление опухолевых клеток. Все чаще испытываются новые протоколы в лечении животных от различных онкологических заболеваний. Длина протокола химиотерапии варьирует от стадии заболевания, клинического проявления и объема поражения, но наиболее эффективным протоколом химиотерапии является CHOP (эндоксан, доксорубицин, винкристин, преднизолон), который рассчитан на 25 недель у кошек. Существуют данные о применении препарата этопозид не только у людей, но и у животных, который может быть эффективным и послужить заменой препарату эндоксан в протоколе лечения СНОР. Но помимо основных методов лечения, важно следить за общим состоянием животного, так как главной целью химиотерапии является продление именно нормального качества жизни животного.</p></abstract><trans-abstract xml:lang="en"><p>Lymphoma in cats is a malignant neoplasm of lymphoid tissue (lymphocytes and other cells of the defense system are affected). Causes of lymphoma in cats can vary, including genetic factors, viruses, and exposure to carcinogens. Most often, patients are admitted to an appointment already with an advanced stage of lymphoma, since the signs of oncological disease are nonspecific and can be easily confused with other diseases of the gastrointestinal tract. Symptoms in cats may include swollen abdominal lymph nodes, decreased appetite and loss of lean body mass, behavioral changes (lethargy, weakness), vomiting, and fever. Lymphoma in cats accounts for 50-90% of all formations of the hematopoietic system. Chemotherapy is one of the main treatments. It consists in the use of cytostatics that inhibit the growth and division of tumor cells. Increasingly, new protocols are being tested in the treatment of animals for various oncological diseases. The length of the chemotherapy protocol varies according to the stage of the disease, clinical manifestation and extent of the lesion, but the most effective chemotherapy protocol is CHOP (endoxan, doxorubicin, vincristine, prednisolone), which is designed for 25 weeks in cats. There are data on the use of the drug etoposide not only in humans but also in animals, which can be effective and serve as a replacement for endoxan in the CHOP treatment protocol. But in addition to the main methods of treatment, it is important to monitor the general condition of the animal, since the main goal of chemotherapy is to prolong the normal quality of life of the animal.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лимфома</kwd><kwd>химиотерапия</kwd><kwd>кошки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lymphoma</kwd><kwd>chemotherapy</kwd><kwd>cats</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gieger, T. (2011). Alimentary Lymphoma in Cats and Dogs. /T. Gieger, // Veterinary Clinics of North America: Small Animal Practice, 41(2), 419–432. doi:10.1016/j.cvsm.2011.02.00 - 2011.</mixed-citation><mixed-citation xml:lang="en">Gieger, T. (2011). Alimentary Lymphoma in Cats and Dogs. /T. Gieger, Veterinary Clinics of North America: Small Animal Practice, 41(2), 419–432. doi:10.1016/j.cvsm.2011.02.00 - 2011.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Paulin, M. V. Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease. /V.M. Paulin, L. Couronné, J. Beguin, S. Le Poder, M. Delverdier, M. Semin,. V. Freiche // BMC Veterinary Research, 14 (1). doi:10.1186/s12917-018-1635-5 - 2018.</mixed-citation><mixed-citation xml:lang="en">Paulin, M. V. Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease. /V.M. Paulin, L. Couronné, J. Beguin, S. Le Poder, M. Delverdier, M. Semin,. V. Freiche // BMC Veterinary Research, 14(1). doi:10.1186/s12917-018-1635-5-2018.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Thamm, D. H. Novel Treatments for Lymphoma. /H. D. Thamm // Veterinary Clinics of North America: Small Animal Practice. doi:10.1016/j.cvsm.2019.04.00 - 2019.</mixed-citation><mixed-citation xml:lang="en">Thamm, D. H. Novel Treatments for Lymphoma. /H. D. Thamm // Veterinary Clinics of North America: Small Animal Practice. doi:10.1016/j.cvsm.2019.04.00 - 2019.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Finotello, R. Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study./R. Finotello, E.M. Vasconi, S. Sabattini, C. Agnoli, C. Giacoboni, M. Annoni, L. Marconato.// Veterinary and Comparative Oncology, 16(1), 159–166. doi:10.1111/vco.12325 - 2017.</mixed-citation><mixed-citation xml:lang="en">Finotello, R. Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study./R. Finotello, E.M. Vasconi, S. Sabattini, C. Agnoli, C. Giacoboni, M. Annoni, L. Marconato.// Veterinary and Comparative Oncology, 16(1), 159–166. doi:10.1111/vco.12325-2017.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Thamm, D. H. Drug Dose, Drug Choice: Optimizing Medical Therapy for Veterinary Cancer. / H. D. Thamm., D.L. Gustafson // Veterinary and Comparative Oncology. doi:10.1111/vco.12537 - 2019.</mixed-citation><mixed-citation xml:lang="en">Thamm, D. H. Drug Dose, Drug Choice: Optimizing Medical Therapy for Veterinary Cancer. / H.D. Thamm., D.L. Gustafson // Veterinary and Comparative Oncology. doi:10.1111/vco.12537-2019.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Трофимцов, Д. В. Онкология мелких домашних животных : Учебное пособие / Д. В. Трофимцов, И. Ф. Вилковыский, М. А. Аверин, А. В. Албул [и др.] // под ред. Д. В. Трофимцова, И. Ф. Вилковыского. - Москва : Издательский дом «НАУЧНАЯ БИБЛИОТЕКА», 2017. – 81 с.</mixed-citation><mixed-citation xml:lang="en">Trofimtsov, D. V. Oncology of small domestic animals: Textbook / D. V. Trofimtsov, I. F. Vilkovysky, M. A. Averin, A. V. Albul [et al.] // ed. D. V. Trofimtsov, I. F. Vilkovysky. - Moscow: Publishing House "SCIENTIFIC LIBRARY", 2017. - 81 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dunleavy, K. Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study. /K. Dunleavy, K., M.A. Fanale, J.S. Abramson, A Noy, P.F. Caimi, S. Pittaluga, W.H. Wilson // The Lancet Haematology, 5(12), e609–e617. doi:10.1016/s2352-3026(18)30177-7 - 2018.</mixed-citation><mixed-citation xml:lang="en">Dunleavy, K. Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study . /K. Dunleavy, K., M.A. Fanale, J.S. Abramson, A Noy, P.F. Caimi, S. Pittaluga, W.H. Wilson // The Lancet Haematology, 5(12), e609–e617. doi:10.1016/s2352-3026(18)30177-7 - 2018.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Boyé, P. Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma. /P. Boyé., F. Serres, L. Marescau, J. Hordeaux., E. Bouchaert, B. Gomes, D. Tierny // PLOS ONE, 12(5), e0177486. doi:10.1371/journal.pone.0177 - 2017.</mixed-citation><mixed-citation xml:lang="en">Boyé, P. Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma. /P. Boyé., F. Serres, L. Marescau, J. Hordeaux., E. Bouchaert, B. Gomes, D. Tierny // PLOS ONE, 12(5), e0177486. doi:10.1371/journal.pone.0177 - 2017.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Paulin, M. V. Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease. /V.M. Paulin, L. Couronné, J. Beguin, S. Le Poder, M. Delverdier, M. Semin,. V. Freiche // BMC Veterinary Research, 14 (1). doi:10.1186/s12917-018-1635-5 - 2018.</mixed-citation><mixed-citation xml:lang="en">Paulin, M. V. Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease. /V.M. Paulin, L. Couronné, J. Beguin, S. Le Poder, M. Delverdier, M. Semin,. V. Freiche // BMC Veterinary Research, 14(1). doi:10.1186/s12917-018-1635-5-2018.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pierro, J. Febrile neutropenia in cats treated with chemotherapy./ J. Pierro, E. Krick, A. Flory, R. Regan, С. DeRegis. // Veterinary and Comparative Oncology, 15(2), 550–556. doi:10.1111/vco.12198 – 2016.</mixed-citation><mixed-citation xml:lang="en">Pierro, J. Febrile neutropenia in cats treated with chemotherapy. / J. Pierro, E. Krick, A. Flory, R. Regan, C. DeRegis. // Veterinary and Comparative Oncology, 15(2), 550–556. doi:10.1111/vco.12198 - 2016.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
