ilvmНормативно-правовое регулирование в ветеринарииLegal regulation in veterinary medicine2782-6252SpbGUVM Publishing House10.52419/issn2782-6252.2023.4.56ilvm-663Research ArticleРЕЗУЛЬТАТЫ НАУЧНЫХ ИССЛЕДОВАНИЙ В ВЕТЕРИНАРИИ. ИНФЕКЦИОННЫЕ БОЛЕЗНИRESULTS OF SCIENTIFIC RESEARCH IN VETERINARY MEDICINE: INFECTIOUS DISEASESТоксины Bacillus anthracis и их роль в патогенезе заболеванияBacillus anthracis toxins and their role in the pathogenesis of the diseaseРодионовА. П.RodionovA. P.

Родионов Александр Павлович, канд.ветеринар.наук

Alexander P. Rodionov, PhD of Veterinary Sciences

ИвановаС. В.IvanovaS. V.

Иванова Светлана Викторовна, канд.биол.наук 

Svetlana V. Ivanova, PhD of Biological Sciences

Федеральный центр токсикологической, радиационной и биологической безопасностиРоссияFederal Center for Toxicological, Radiation and Biological SafetyRussian Federation202324012024045661Copyright © Родионов А.П., Иванова С.В., 20232023Родионов А.П., Иванова С.В.Rodionov A.P., Ivanova S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ilvm.elpub.ru/jour/article/view/663

В обзорной статье приводятся актуальные результаты разносторонних исследований, направленных на изучение токсинов Bacillus anthracis. Показаны структурные особенности протективного антигена, летального и отечного факторов. Представлен механизм транслокации комплекса токсинов в цитозоль клетки. Проанализированы направленность действия летального и отечного токсинов на клетки восприимчивого организма и механизмы их цитотоксичности. Описаны механизмы действия токсинов на ранних и системных стадиях развития инфекции. Выявлены вопросы, касающиеся взаимодействия токсинов с клетками-мишенями и их действия на различные органы и ткани макроорганизма, нуждающиеся в дальнейших глубоких исследованиях.

The review article presents the relevant results of comprehensive studies aimed at studying the toxins of Bacillus anthracis. The structural features of protective antigen, lethal and edematous factors are shown. The mechanism of translocation of a complex of toxins into the cytosol of the cell is presented. The orientation of the action of lethal and edema toxins on the cells of a susceptible organism and the mechanisms of their cytotoxicity are analyzed. The mechanisms of action of toxins in the early and systemic stages of infection are described. Issues have been identified regarding the interaction of toxins with target cells and their effects on various organs and tissues of the macroorganism, which require further in-depth studies.

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The authors declare that there are no conflicts of interest present.