Effectiveness of immunostimulator RV-1 for castration of piglets

Abstract

Castration, like any surgical intervention, is accompanied by changes on almost all levels of immunity - macrophage-phagocytic, humoral and cellular, which does not exclude the possibility of postoperative complications. In experiments on two groups of piglets (control and experimental ones, n = 4 in each), two treatment regimens of post-castration wounds were tested - the baseline and experimental ones - with the inclusion of the immunomodulator RV-1 from the group of natural compounds on an alcohol basis, which is a complex balanced composition of biologically active substances. Studies have shown that the local application of the immunomodulator RV-1 in combination with streptocid and “Fortidin-Spray” stimulates the process of tissue regeneration, accelerating the healing rate of the wound. Thus, the dynamics of the area and the percentage of its decrease, the rate of wound healing in the experimental group compared to the control group during all the observation days were more intensive. The most pronounced differences were registered in the seven to thirteen-day period (P< 0,05). The indices of the area decrease in the experimental group had a reliable character (P< 0,05 - 0.001., in the control group in most cases they tended to it. The use of the immunomodulator RV-1 contributed to a reduction in the wound healing time by 2.5 days - up to 14.75 ± 0.48 days compared to 17.25 ± 0.85 in the control. It is shown that the preparation is also growth-stimulating. An assumption is made about the prospects of local immunocorrection for other operative interventions in animals.