Indicators of cellular immunity in cows with genital Mycoplasmosis

Abstract

Urogenital mycoplasmosis is currently widespread in livestock farms both in our country and abroad. Unfortunately, today we have little data on the pathogenesis of this disease, and in particular on the state of the immune system of cows with genital mycoplasmosis. We have carried out a comparative study of indicators of cellular immunity in healthy cows and cows with genital mycoplasmosis. The study was carried out on pregnant cows. In healthy and mycoplasma-infected cows, the relative and absolute content of lymphocyte subpopulations was determined. It has been established that with genital mycoplasmosis in cows there is a significant decrease in the number of leukocytes and a decrease in the relative and absolute content of B-lymphocytes. Thus, infected animals develop a moderate immunodeficiency state due to prolonged exposure to mycoplasma metabolites, which inhibit the proliferative activity of immunocompetent cells. These changes should be taken into account when developing treatment regimens for genital mycoplasmosis.