Relationship of beta-hydroxybutyrate hyperproduction and intensity of gluconeogenesis in cows in the earlt new-calving period on the background of subclinical and clinical ketosis
https://doi.org/10.52419/issn2782-6252.2022.3.62
Abstract
The article presents the results of a routine examination of cows on the fifth day after calving for the content of betahydroxybutyric acid and glucose in the blood. Out of a total number of analyzes from 452 cows, results from 208 animals with elevated levels of beta-hydroxybutyrate were selected and grouped according to this indicator. An analysis of the ratio of the indicator with the level of glucose in the blood of cows was carried out and an inversely proportional relationship was found within the range of beta-hydroxybutyrate from 1.0 to 3.4 mmol/l. Further growth of BHB occurs in conjunction with the development of hypoglycemia. A decrease in glucose levels is the cause of not only the activation of ketogenesis, but also the triggering of protein proteolysis and gluconeogenesis based on amino acids. Therefore, an increase in the level of βhydroxybutyric acid to 3.65 ± 0.10 mmol/l is accompanied by an imaginary normalization of the glucose concentration, although this mechanism of glucose conversion is maintained due to an extremely undesirable process in this period protein catabolism. An increase in the BHB level above 4.0 mmol/l leads to uncoupling of gluconeogenesis and a decrease in glucose below the physiologically acceptable values. When conducting a correlation analysis, a strong negative relationship was found in the concentration range of β-hydroxybutyric acid (according to the average group values) from 1.20±0.01 to 3.20±0.11 (r= 0.97). In the study within the entire studied range from 1.20±0.01 to 4.80±0.17, the interaction strength decreases (r= -0.59).
About the Author
S. V. Vasilyeva
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Svetlana V. Vasilyeva, PhD of Veterinary Sciences, Docent
References
1. Agro-industrial complex of the Leningrad region and St. Petersburg in 2021. Statistical bulletin. St. Petersburg, Petrostat. 2022. 47 p.
2. Vasilyeva, S. V. Clinical biochemistry of cattle: a textbook for universities / S. V. Vasilyeva, Yu. V. Konopatov. 3rd edition, stereotypical. St. Petersburg: Publishing house "Lan", 2021. 188 p.
3. Nikitina, A. A. Prevalence and diagnosis of subclinical ketosis in dairy cows during the transition period / A. A. Nikitina // Proceedings of the 75th anniversary international scientific conference of young scientists and students of St. V.V., Year of Science and Technology, St. Petersburg, April 05–09, 2021. St. Petersburg: St. Petersburg State University of Veterinary Medicine, 2021. P. 159-161. – EDN MZDJEX.
4. Clinical biochemistry of domestic animals / Ed. by: J. J. Kaneko, J. W. Harvey, M. L. Bruss. – 6th ed. – NY: Academic Press, 2008. – 928 p.
5. Elevated non-esterified fatty acids and βhydroxybutyrate and their association with transition dairy cow performance. / J.A McArt., D.V. Nydam, G.R. Oetzel, [et al.] // Vet J. 2013 Dec; Vol. 198. – No 3. – P. 560-570.
6. Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough / [J. R. Aschenbach, N. B. Kristensen, S. S. Donkin et al.] // IUBMB Life. – 2010. – Vol. 62, № 12. – P. 869–877.
7. Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows / [G. Esposito, P. C. Irons, E. C. Webb et al.] // Anim. Reprod. Sci. – 2014. – Vol. 144, No. 3–4. – P. 60–71.
8. Pregnant Cows and Heifers Blood Profile Comparison / I. Kozitсyna, L. Yu. Karpenko, A. A. Bakhta [et al.] // Advances in Engineering Research, Tyumen, 16–20 июля 2018 года. – Tyumen: Atlantis Press, 2018. – P. 391-396.
9. Study of metabolic processes in cows with hyperbilirubinemia in the postpartum period / A. Nikitina, S. Vasileva, R. Vasilev [et al.] // FASEB Journal. – 2022. – Vol. 36. – No S1. – P. 3431. – DOI 10.1096/ fasebj.2022.36.S1.R3431. – EDN VDGVPC.
Review
For citations:
Vasilyeva S.V. Relationship of beta-hydroxybutyrate hyperproduction and intensity of gluconeogenesis in cows in the earlt new-calving period on the background of subclinical and clinical ketosis. Legal regulation in veterinary medicine. 2022;(3):62-65. (In Russ.) https://doi.org/10.52419/issn2782-6252.2022.3.62
Views:
167
Email this article 