Nonlinear elimination of pharmaceutical substances in multi-compartment and non-compartment pharmaco-kinetic models

Abstract

Currently, about 90% of drug kinetics studies published in specialized veterinary journals are based on classical compartmental models. This contrasts with the situation in medical pharmacology, where non-compartmental analysis and alternative novel approaches are increasingly being used. These approaches are becoming increasingly important not only for characterizing drug distribution and concentration versus potency in therapeutic applications, but also for regulating the safety levels of chemicals in industrial settings and in animal products.

A compartment is considered open if it interacts with the environment, or closed if it does not interact. In pharmacokinetics, most models in use have at least one open compartment with first-order elimination.

The selection and analysis of scientific publications was carried out according to the recommendations of H. Snyder for writing review articles.

In English and Russian, in various bibliographic databases (Elibrary, Pubmed, Scopus(Elsevier), Web of Science (Clarivate)) thematic publications were searched by keywords with further highlighting the most cited ones. Articles published earlier than 2015 were used only if they contained information critical to the disclosure of the topic that was not found in later publications.

This publication summarizes the various approaches that are currently being used to analyze kinetic data and will stimulate interest in applying some of these new approaches to studying drug distribution in different animal species. Undoubtedly, without the use of alternative and/or new models, it would be difficult to improve our experimental approaches and understand the complex pharmacological differences between animal species.