The effect of synthetic peptide bioregulators on the expression of piglet T-lymphocyte receptors to sheep erythrocytes in vitro loading tests

Abstract

To identify the functional reserve of immunocompetent cells in sick piglets and to predict the appointment of immunomodulators, rosette formation loading tests with synthetic peptide bioregulators thymogen and synthetic bone marrow pentapeptide (SPCM) were performed. Also, loading tests were carried out in groups of animals in the treatment of which the above drugs were used. As a result of studies, it was found that during acute bronchopneumonia, the 14th day is the critical period for the activation of immunocompetent cells. The use of immunomodulators in the treatment of bronchopneumonia allows to avoid a drop in the activity of T-lymphocytes during this period, and to a greater extent affects the activation of T -lymphocytes by thymogen used as part of the complex therapy of sick animals.