Fluxomics as a methodological tool for designing drugs
https://doi.org/10.52419/issn2782-6252.2023.1.72
Abstract
This article defines fluxomics as a biomedical science and an area of metabolic research, which is used as a methodological tool for the design of medicinal substances, including for veterinary use.
The scientific novelty of the publication lies in the complexity of the ongoing review of existing research in the field of the latest methods of designing pharmaceutical substances (including those based on digital transformation), such as the study of cell flux, with a description of the main methodological approaches and principles. The main author's hypothesis of this study is the possibility of identifying the most promising approaches in terms of veterinary pharmacology for their further possible introduction into industry practice.
The purpose of the review is to substantiate the priority use of the Fluxomics methodology as a stage in the development of new drugs for veterinary use with the study of the main methodological approaches.
The information retrieval methodology was based on such general scientific methods of cognition as: a review of specialized search engines and databases of scientific and research data (Scopus, WoS, PubMed) over the past 10 years, of which the most informative ones were selected, analysis of the identified results, and their comparison by relevance.
As a result of the analysis, the role of fluxomics in the structure of "ohmic" sciences was revealed, the main concepts that determine the development of fluxomics as a set of algorithms for the study of metabolic networks, analytical and instrumental methods for implementing fluxomic models were considered, the main problems and prospects for using this methodological apparatus in the context of designing and further validation of drug candidate substances.
About the Author
V. S. Ponamarev
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
PhD in Veterinary Sciences
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Review
For citations:
Ponamarev V.S. Fluxomics as a methodological tool for designing drugs. Legal regulation in veterinary medicine. 2023;(1):72-75. (In Russ.) https://doi.org/10.52419/issn2782-6252.2023.1.72
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