Acute toxicity of a new antiseptic for veterinary dentistry
https://doi.org/10.52419/issn2782-6252.2023.1.95
Abstract
The development steps of new drugs require consistent safety and efficacy studies in animals. This article reflects the research of a new antiseptic for veterinary dentistry containing active ingredients such as chlorhexidine bigluconate and propolis. Acute toxicity studies were carried out following the “Guidelines for the experimental (preclinical) study of new pharmacological substances” (2005), according to GOST 32644-2014 and taking into account the requirements of the Order of the Ministry of Agriculture of the Russian Federation of March 6, 2018 No. 101. rats with an average live weight of 250-280 grams, from which one experimental group of three animals was formed (for the first stage of the study), after receiving the results of the first stage, a second experimental group of three animals was formed for the second stage. The rats of the experimental groups were injected with the studied antiseptic once into the inside of the stomach using a special club-shaped needle at a dose of 2000 mg/kg. As a result of the experiment, it was found that the investigated new antiseptic containing chlorhexidine bigluconate and propolis, intended for the treatment of inflammatory processes in the oral cavity in animals, belongs to substances of hazard class V according to GOST 32644-2014. There were no deaths of animals during the experiment.
About the Author
V. V. Kolesova
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
PhD student
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Review
For citations:
Kolesova V.V. Acute toxicity of a new antiseptic for veterinary dentistry. Legal regulation in veterinary medicine. 2023;(1):95-97. (In Russ.) https://doi.org/10.52419/issn2782-6252.2023.1.95
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