Study of acute toxity and wound healing effect of the complex ointment «Uberosept»
https://doi.org/10.52419/issn2782-6252.2023.4.124
Abstract
The design of drugs that allow the unlimited use of animal products is an important area of veterinary pharmacology. In this regard, in the production of a new complex ointment intended for treating the skin of the udder of cows, natural components were selected. The formula for “Uberosept” ointment includes ichthyol, pine resin and camphor. One of the important stages of preclinical study of new drugs is to identify their toxic properties and evaluate their efficacy. Therefore, the purpose of our work was to determine the toxicity class and study the wound-healing effect of “Uberosept”.
The acute toxicity of “Uberosept” ointment was tested during intragastric administration using a fixed dose method (GOST 32296-2013) on female white mice. The wound healing effect was studied in a full-thickness skin wound model in female rats.
It has been established that “Uberosept” ointment can be classified as hazard class 5. When administered intragastrically at a maximum dose of 5000 mg/kg during the first 30 minutes and the next 14 days, no signs of intoxication were detected in all experimental mice.
About the Authors
A. R. Peregonchiy
All-Russian Research Veterinary Institute of Pathology, Pharmacology and therapy
Russian Federation
Russian Federation
A.R. Peregonchiy
L. V. Cheskidova
All-Russian Research Veterinary Institute of Pathology, Pharmacology and therapy
Russian Federation
Russian Federation
L.V. Cheskidova, Dr.Habil. in Veterinary Sciences
I. V. Bryukhova
All-Russian Research Veterinary Institute of Pathology, Pharmacology and therapy
Russian Federation
Russian Federation
I.V. Bryukhova, PhD of Veterinary Sciences
O. B. Pavlenko
All-Russian Research Veterinary Institute of Pathology, Pharmacology and therapy
Russian Federation
Russian Federation
O.B. Pavlenko, Dr.Habil. in Biological Sciences
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Review
For citations:
Peregonchiy A.R., Cheskidova L.V., Bryukhova I.V., Pavlenko O.B. Study of acute toxity and wound healing effect of the complex ointment «Uberosept». Legal regulation in veterinary medicine. 2023;(4):124-128. (In Russ.) https://doi.org/10.52419/issn2782-6252.2023.4.124
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