Changes in indicators of hepatocellular damage and cholestasis in connection with bilirubin level in horses
https://doi.org/10.52419/issn2782-6252.2024.2.106
Abstract
The article describes the results of a study in the blood of horses of hepatospecific markers – the enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT), which were ranked by bilirubin concentration. The conducted studies revealed the relative constancy of enzymes – markers of hepatocellular damage and cholestasis in the ranges of bilirubin values from 5.9 to 20.0 mmol/L. At a bilirubin concentration from 20.0 to 25.0 mmol/l, there are signs of an increase in the activity of all the studied enzymes, but the changes are not statistically significant. At bilirubin concentrations from 30.0 to 48.3 mmol/l, there was a significant increase in ALT by 46.4%, AST by 20.4% and GGT by 36.0%. Correlation analysis of the studied enzymes against the background of hyperbilirubinemia showed the presence of a strong positive relationship between the enzymes markers of cytolysis ALT and AST (Pearson coefficient r=0,89) and between the enzymes markers of cholestasis GGT and alkaline phosphatase (Pearson coefficient r=0,72). It was found, that unidirectional changes are observed only in either markers of hepatocyte cytolysis or markers of cholestasis. A significant relationship between enzymes of different cellular localization has not been established.
About the Authors
S. V. Vasilyeva
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Svetlana V. Vasilyeva, PhD of Veterinary Sciences, Docent
A. V. Prusakov
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Alexey V. Prusakov, Dr.Habil. of Veterinary Sciences, Docent
M. S. Golodyaeva
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Maria S. Golodyaeva, PhD of Veterinary Sciences
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Review
For citations:
Vasilyeva S.V., Prusakov A.V., Golodyaeva M.S. Changes in indicators of hepatocellular damage and cholestasis in connection with bilirubin level in horses. Legal regulation in veterinary medicine. 2024;(2):106-109. (In Russ.) https://doi.org/10.52419/issn2782-6252.2024.2.106
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