Selection of a consortium of Chlamydia psittaci antigens for the construction of a multispecies vaccine against animal Chlamydia

Abstract

Chlamydia of farm animals is an infectious disease that poses a potential threat to human health due to the possibility of disease as a result of contact with infected animals and birds. To date, vaccination remains the main method of prevention and control of infection. Currently, there is a question of developing preventive vaccines containing antigens in their composition, which make it possible to create stable immunity in most species of farm animals, which will expand the range of consumers due to economic benefits. The paper presents the results of studies on the selection of antigens from strains of the causative agent of chlamydia, which will serve as the basis for the design of a preventive drug that protects against infection. Antigens were obtained from strains isolated from various animal species with different forms of pathology. Chl. psittaci was cultured on developing chicken embryos, antigens were obtained from yolk membranes, inactivated and purified. The obtained antigens were studied for sterility, harmlessness, antigenic activity and immunogenicity for laboratory animals. The selection of the consortium was carried out on the basis of the conducted research. Antigens from strains 250, PC-85, AMK16 Chl. psittaci were selected as components for the future polyvid vaccine against chlamydia in farm animals.