The effect of probiotics, prebiotics and synbiotics on the restoration of the clinical state and balance of the intestinal microbiome after antibiotic therapy

The aim of the study was to establish the degree of influence of probiotics, prebiotics and synbiotics on the restoration of the clinical condition and balance of the intestinal microbiome of animals after antibiotic therapy.

We studied 20 cats of different ages who underwent antibacterial therapy using the drug Ceftriaxone at a dose of 20.0 mg per kg of body weight 2 times a day, in the form of intramuscular injections, divided into four groups, each of which included five animals.

The animals of the first group were prescribed the probiotic "Subtilis". The latter was administered orally in a dose of 8 drops, for 14 days. Animals of the second group were prescribed the probiotic "Subtilis" at the same dose and with the same multiplicity, as well as the prebiotic "Vetelact" in addition to it, at the rate of 0.1 ml per 1.0 kg of body weight daily for 14 days. The animals of the third group were administered orally the synbiotic "Evitalia-Vet" 1 tablet for 14 days. The fourth group was a control group. The animals included in it were under observation and did not receive any drugs.

It was found that the restoration of the clinical state and balance of the intestinal microbiome after antibiotic therapy was most intensive in animals receiving the probiotic "Subtilis" and the prebiotic "Vetelact". Under the influence of these drugs, at the end of treatment, the level of hemoglobin, erythrocytes and hematocrit decreased by 22.0%, 19.0% and 15.7%, respectively, in animals receiving them, compared with the indicators before it began. Also, in comparison with other groups, animals receiving the probiotic "Subtilis" and the prebiotic "Vetelact" showed a more pronounced decrease in the level of urea and total protein in blood serum, while the number of lactobacilli at the end of treatment was 42.0% higher, and the population of E. coli decreased by 37.0%, in comparison with control.

Thus, the simultaneous administration of probiotics and prebiotics to animals after undergoing antibiotic therapy gives the most effective result, manifested in the accelerated restoration of their clinical condition and the balance of the intestinal microbiome.

1. Alexeyeva, I. G. Infectingchain painful melkih domestic animalcule: educational tool ( s). G. Alexeyeva, V. P. Dorofeeva, M. V. Markova. - Omsk: Omsk gau, 2019. - 121 PP. — ISBN 978-5-89764-841-2.

2. Velikanov, V. And. Medicinalmedicine, modifiable repeatability in veterinary medicine : educational toolkit for vuzov / Vu. And. Velikanov, E. A. Elysian; edited by V. And. Velikanov. - 3rd ed. Sterr. - St. Petersburg: Lange, 2024. - 176 PP. — ISBN 978-5-507-49673-0.

3. Sandul, A.V. Correxia kishechnog bacteriocenosis in degelminthizirovaniandeng sobak with priming prebiosa 600 and biolactovita.V. Sandul, V.V. Korsakov / / Scientist / notes institutions of Education "Vitebskaya order" sign honor "State Academy of Veterinary Medicine". — 2011. — № 2-1. - S. 197-199. — ISSN 2078-0109.

4. Squeal, Oh.V. Pathogenetic rationale for pro-bitox pet in sobak and koshek dyspepsia. V. Quack, L. A. Lukoyanova / / International Vets Journal. — 2019. — № 4. - S. 94-100. — ISSN 2072-2419.

5. Kuznetsova, N.V. Study of effects of cormovia supplements in painful non-infective extravetiologies with diarain urgum syndrome in sobak / N. V. Kuznetsova, V. V. Peiterova, Yu. Well. Kuznetsov / / International Urga newspaper veterinarians. — 2021. — № 1. - S. 73-80. — ISSN 2072-2419.

6. Kuleshova, T. G. Immunomodulator Urga, globulin Urga, with urgunvotki, anatoxin Urga and preparation Urga activating immune system: textbook / t. G. Kuleshova, S. M. Kuleshov. - Ussuriysk: Primorsky Gatu, 2007. - 114 PP.

7. Lymphoid Tanka stanky Tolstoy kishky Volka-Urga / a. B. Panfilov, N. V. Zelenevsky, M. V. Shippakin [etc. Medical Immunology. – 2017. - T. 19, № S. - S. 426.

8. Molyanova, G.V. Action ambiguusperimental synbiotics BLABD - 1 in complex with digidroquercetinoma of microflora kishechnica officermana sobak / G. V. Molyanova, V. V. Yermakov, I. A. Akulova / / Izvestia Samar State School Village Academies. — 2019. — № 3. - S. 69- 77. — ISSN 1997-3225.

9. Replacement of probiotic Vetom 1 in complex therapies microsporia koshek. G. Nostril, M. S. Yakovleva, N. S. Yakovleva, E. Well. Pistunova / / Ngau newspaper. — 2020. — № 4. - S. 125-130.

10. Sepp A.L. Substitution probiotic stamma is aposematic in gastroenterologists U Porosyat / Yashin A.V., Radnatarov V.D. // Newspaper Buryat State School of the Village Academy. V.R. Philippova. – 2020. № 3(60). - S. 74–80. doi: 10.34655/bgsha.2020.60.3.011

11. Shavrov, S. S. Ambiguities of probiotics "bifidum-CJ" in the treatment of dyspepsia non-specific empirereferencesexternal links S. Shavrov, A. V. Prusakov / / problem Evaluative development of livestock and IH solution :, Bryansk, 25-26 March 2021. - Bryansk: Bryansk State University, 2021. - S. 432-436.

12. Yashin, A.V. Particularities with the long microcirculator bed and membranous tibia in the new-born Penghu calf in dyspepsia. V. Yashin, A. V. Prusakov / / International Vets Journal. — 2021. — № 2. - S. 155-160. — ISSN 2072-2419.

13. Yashin A.V. Dysbacteriosis in animalcamp: theoretical and inferential asbaexample aspect Urga / Shcherbakov G.G., Kovalev S.P., Guseva V.A., Kulyakov G.V., Klusko D.A. // Ipology and veterinary. – 2019. – № 4(34). - S. 159–162.