Studying the tolerability of a drug based on Amoxicillin and Succinic acid on piglets

Abstract

To date, an important task is the development of medicines based on antibiotics and excipients with an active effect. Such combinations, in turn, should enhance the susceptibility of microorganisms to chemotherapeutic agents [1]. The main purpose of our experiments was to study the tolerability of a drug based on amoxicillin and succinic acid on piglets in therapeutic and fivefold doses [5]. The tests were carried out at a pig breeding complex in the Leningrad region. All selected piglets of a large white breed were quarantined for seven days, after which they were admitted to the experiment. 60 healthy piglets, two months old with an average body weight of 25 kg, were divided into 3 groups: 2 experimental and 1 control group of 20 animals each. One of the experimental groups was administered the drug with feed at a dose of 0.0175 g per kg of body weight, the second at a fivefold increased dose of 0.0875 g per kg of body weight 1 time once for 10 days. Based on the data obtained to study the tolerability of a drug based on amoxicillin and succinic acid, we found that using it with food once, for 10 days in a therapeutic 0.0175 g and in a fivefold increased dose of 0.0875 g per kg of body weight did not have a pathological effect on the body of the piglets tested. During the experiment, all animals remained alive, the indicators of the control and experimental groups were within the reference range and did not significantly differ from each other. The results obtained confirm the safety of using the drug based on amoxicillin and succinic acid in the recommended dosage regimen.