Pharmacokinetics of the drug Amoxyantar in pigs
https://doi.org/10.52419/issn2782-6252.2024.3.98
Abstract
The article presents the results of pharmacokinetic studies of the drug Amoxiyantar in pigs. The results obtained indicate that amoxicillin is distributed throughout the tissues of animals, providing therapeutic concentrations in the studied dosage, ensuring effective distribution in the organs and tissues of the body of pigs, and also confirm the bioavailability of succinic acid with a high concentration in the blood plasma for an average of two hours. Based on the results of determining the dynamics of excretion of residual amounts of amoxicillin, it was detected in only one animal in the kidneys at a concentration of 54.9 μg/kg and in muscle tissue at a concentration of 25.2 μg/kg. In the remaining tissue samples of pigs obtained two days after application of the drug, as well as in all tissue samples of pigs obtained from the sixth day to the 18th day after application of the drug, amoxicillin was not detected.
About the Authors
S. V. Engashev
LLC "Scientific and innovation center Agrovetzashchita"
Russian Federation
Russian Federation
Dr.Habil. in Veterinary Sciences, Prof., Academician of the Russian Academy of Sciences
A. A. Komarov
Moscow State University of Food Production (ROSBIOTECH)
Russian Federation
Russian Federation
Dr.Habil. in Biological Sciences, Prof., Professor of the Russian Academy of Sciences
A. M. Lunegov
Sankt-St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
PhD of Veterinary Sciences, Docent
A. S. Khlebalina
"All-Russian Scientific Research Veterinary Institute of Poultry Farming" (VNIVIP) - branch of the Federal Scientific Center "All-Russian Scientific and Technological Institute of Poultry Farming" VNITIP
Russian Federation
Russian Federation
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Review
For citations:
Engashev S.V., Komarov A.A., Lunegov A.M., Khlebalina A.S. Pharmacokinetics of the drug Amoxyantar in pigs. Legal regulation in veterinary medicine. 2024;(3):98-101. (In Russ.) https://doi.org/10.52419/issn2782-6252.2024.3.98
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