Content of Ceruloplasmin and Fibrinogen in cattle with catarrhal mastitis
https://doi.org/10.52419/issn2782-6252.2024.4.55
Abstract
Acute phase proteins are the main tool for assessing the nature of the inflammatory process, monitoring treatment and part of the indicator of the internal state of animals in diseases of various origins. One of the most famous in diagnostic practice is the determination of the content of fibrinogen in the blood. Determination of the level of ceruloplasmin in veterinary medicine for diagnostic purposes is not so common, but it is an important marker of inflammation in the body. The aim of the study is to determine the content of ceruloplasmin and fibrinogen in cattle with catarrhal mastitis. Studies were conducted in Holstein cows divided into two groups: 1st - clinically healthy animals (n = 20) and 2nd - with signs of catarrhal mastitis (n = 20). The amount of ceruloplasmin was determined by Ravin's method. Fibrinogen concentration was determined by the Rutberg method. As a result of studies, a significant increase in ceruloplasmin was found in animals of the second group 694.75 ± 98.88 mg/l compared to clinically healthy animals 426.56 ± 25.59 mg/l. The level of ceruloplasmin in mastitis was increased due to the fact that the mammary gland is one of the sources of ceruloplasmin production in the body, and leukocytes migrating to the focus of inflammation are also the source of this protein. Fibrinogen content in patients was 6.77 ± 0.9 g/l versus 3.55 ± 0.6 g/l in healthy patients. An increase of the fibrinogen in animals with catarrhal mastitis confirms that inflammation make disorders in the coagulation and anticoagulation systems of the blood towards an increased tendency to thrombosis. Thus, the determination of the contents of the acute phase proteins in blood, such as ceruloplasmin and fibrinogen, is an important diagnostic tool for assessing the state of the body, and also indicates the nature of the process in the body.
About the Authors
O. V. Kryachko
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Oksana V. Kryachko, Dr. Habil. In Veterinary Sciences, prof.
A. V. Chartoriiskaia
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Arina V. Chartoriiskaia, PhD student
References
1. Voronina OA, Zaitsev SY, Savina AA, Kolesnik NS. Evaluation of the content of ceruloplasmin, copper and copper-coordinating amino acids in cow milk at different lactation periods. Agrarian science of the Euro-Northeast. 2023;24(6):1038-1048. https://doi.org/10.30766/2072-9081.2023.24.6.1038-1048
2. Kryachko, O. V. Approbation of the methodology for determining the concentration of plasma ceruloplasmin in dogs/O. V. Kryachko, A. V. Chartoriiskaia, //AIC - youth, science, innovation: Materials of the Student Scientific and Practical Conference, Grozny, May 16, 2024. - Grozny: Chechen State University named after Akhmat Abdulkhamidovich Kadyrov, 2024. - P. 22-26. – DOI 10.36684/123-1-2024-22-26. – EDN JWFNBL.
3. Kamyshnikov V.S. Handbook for Clinical and Biochemical Research and Laboratory Diagnostics. - Moscow: MEDpress-inform, 2009. - 896 р.
4. Letunovskaya A.V. Ceruloplasmin in breast pathologies of a non-inflammatory nature in females / A.V. Letunovskaya //European journal of biomedical and life sciences, no. 1, 2017, pp. 63-66.
5. Fundamentals of clinical veterinary hematology: a textbook for universities/S.P. Kovalev, A.V. Tuvardzhiev, V.A. Konoplev, R.M. Vasiliev. - 2nd edition, stereotypical. - St. Petersburg: Publishing house "Lan," 2023. - 120 p. - ISBN 978-5-507-47198-0. – EDN UYPBGR.
6. Pathological animal physiology. General nosology. Typical pathological processes/O. V. Kryachko, L. A. Lukoyanova, V. N. Gaponova [et al.]. - St. Petersburg: St. Petersburg State University of Veterinary Medicine, 2022. – 151 p. – EDN OGAIQR.
7. Plemyashov K.V., Filatova A.V., Sandakchi D.N., Avdeenko V.S. Metabolic indicators in the diagnosis and prognosis of the course of subclinical and clinical mastitis in goats after lambing. Regulatory regulation in veterinary medicine. 2022;(4):72-77. https://doi.org/10.52419/issn2782-6252.2022.4.72
8. Sanina, O. L. Biological role of ceruloplasmin and possibilities of its clinical use. Literature review/O. L. Sanin, N. K. Berdinsky//Vopr. med. chemistry. - 1986. - T. 32. - N 5 - P. 7-14.
9. Chartoriiskaia, A. V. The specifity of the acute phase proteins in dogs with various diseases of inflammatory origin / A. V. Chartoriiskaia //, November 23–24, 2023. - St. Petersburg, 2023. – P. 470-472. – EDN CCXSNX.
Review
For citations:
Kryachko O.V., Chartoriiskaia A.V. Content of Ceruloplasmin and Fibrinogen in cattle with catarrhal mastitis. Legal regulation in veterinary medicine. 2024;(4):55-57. (In Russ.) https://doi.org/10.52419/issn2782-6252.2024.4.55
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