Comparative assessment of models of experimental stress in rabbits by change of hematological and metabolic indicators

Abstract

In the framework of this work, a comparative analysis of the depth of hematological and metabolic disorders in rabbits in the simulation of stress by different methods is presented. Models of transport and immobilization stress for rabbits were used and the main hematological and biochemical indicators were studied according to generally accepted methods. As a result of the research, it was established that when implementing various models of stress in the body of animals, the same type of changes occurred, typical for the simulated pathological process: hyperglycemia, hypercortisolemia, changes in the activity of enzymes involved in protein metabolism. Changes in hematological parameters characterized the so-called "stressful" blood - neutrophilia, lymphocytopenia, a tendency to erythropenia and reliable thrombocytosis. Deeper changes in indicators were in the implementation of the model of immobilization stress. On the basis of the studies carried out, we can suggest using a more gentle model of stress for animal studies - transportation of animals. Firstly, this effect is often experienced by animals in real life, and secondly, changes from the studied indicators do not have significant differences from those in the implementation of the immobilization stress model.