Influence of complex feed additive on the microstructure of the spleen of white rats

Abstract

When assessing the impact of various drugs (including feed additives), information on their effect on the proliferation of cells in the immunogenesis organs is very important. The feed additive was administered orally using an atraumatic probe in the form of a powder suspension for 90 days: the first group of rats served as a control, they were given tap water and compound feed; animals of the second experimental group received tap water with a feed additive in the form of fish meal at a dose of 800 mg / kg; and the third group - at a dose of 600 mg / kg. It was found that when using a complex feed additive (fish meal) in different doses, no significant changes in the clinical status of white rats are observed. Evaluation of the linear values of the rat spleen (length, width, thickness, diameter) showed that they were at the level of control animals. The average body weight of animals in the experimental groups was almost at the level of control rats. It was also found that the change in spleen weight was parallel to the increase in body weight of rats. This characterized their proportional growth and development. According to the results of the study of the histological picture of the spleen, it can be concluded that, despite the different doses of the feed additive, there are no visual changes in the organ at the microstructure level. The studies were conducted as part of the scientific work on the topic "Hygiene of processing biological waste by microbial synthesis."