Determination of the degree of cumulation of an aqueous solution of a chelate complex of microelements for animals

Abstract

The paper describes the results of studying the cumulative properties of an aqueous solution of a chelated complex of trace elements for intramuscular administration. Two groups of animals were formed: the first group was injected intramuscularly with water for injection, and the animals of the second experimental group were given an aqueous solution of a chelated complex of trace elements containing iron, manganese, copper, selenium, and iodine. The dose was calculated based on the dose established in the previous series of experiments, in the first four days of the experiment, the dose of the administered drug was 0.1 of LD50 (90.7± 0.63 mg/kg). Then, according to the recommendations for the degree of accumulation, the dose was increased 1.5 times every four days. The animals were monitored daily, during which clinical manifestations were noted, survival was assessed, as well as the results of a macroscopic visual examination of changes in internal organs.