Monitoring antibiotic resistance of pathogens causing bronchopneumonia in young cattle
https://doi.org/10.52419/issn2782-6252.2025.2.55
Abstract
Respiratory diseases in cattle remain the most common in livestock complexes. Testing for sensitivity to antimicrobial drugs using phenotypic methods is key in monitoring programmes for the early detection of resistance development and tracking trends in resistance development necessary for adjusting treatment and prevention measures in livestock farming. In the course of our research, we established the sensitivity of bronchopneumonia pathogens (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Moraxella bovoculi, Mannheimia haemolytica) isolated from calves in livestock complexes in the Leningrad Region. The results demonstrate the insufficient effectiveness of the therapeutic measures carried out with the use of antibacterial drugs, which is associated with the resistance of a number of bronchopneumonia pathogens. Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, and Pseudomonas aeruginosa showed phenotypic resistance to the antimicrobial drugs tested. The data obtained as a result of monitoring can be used for scientific research aimed at improving treatment and preventive measures in livestock farming.
About the Authors
M. V. Kiyanchuk
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Margarita Vl. Kiyanchuk - Postgraduate student, Department of Microbiology, Virology and Immunology, Assoc. Department of Biochemistry and Physiology
A. A. Sukhinin
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Aleksandr Al. Sukhinin - Dr. of Biological Sciences, Professor, Head of Department of Microbiology, Virology and Immunology
References
1. Ayeh-Kumi P.F., Tetteh-Quarcoo P.B., Duedu K.O., Obeng A.S., Addo-Osafo K., Mortu S., Asmah R.H. A survey of pathogens associated with Cyperus esculentus L (tiger nuts) tubers sold in a Ghanaian city. BMC Res Notes. 2014 Jun 6;7:343. doi: 10.1186/1756-0500-7-343. PMID: 24906387; PMCID: PMC4071804.
2. Lee C.R., Lee J.H., Park K.S., Jeon J.H., Kim Y.B., Cha C.J., Jeong B.C., Lee S.H. Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms. Front Cell Infect Microbiol. 2017 Nov 21;7:483. doi: 10.3389/fcimb.2017.00483. PMID: 29209595; PMCID: PMC5702448.
3. Lubbers B.V., Hanzlicek G.A. Antimicrobial multidrug resistance and coresistance patterns of Mannheimia haemolytica isolated from bovine respiratory disease cases--a three-year (2009-2011) retrospective analysis. J Vet Diagn Invest. 2013 May;25(3):413-7. doi: 10.1177/1040638713485227. Epub 2013 Apr 9. PMID: 23572456.
4. Maboni G., Gressler L., Pires E.J., Schwab M., Tasca C., Potter L., Vargas A. Differences in the antimicrobial susceptibility profiles of Moraxella bovis, M. bovoculi and M. ovis. Brazilian Journal of Microbiology. 2015. 26. 545. 10.1590/S1517-838246220140058.
5. Magstadt D.R., Schuler A.M., Coetzee J.F., Krull A.C., O'Connor A.M., Cooper V.L., Engelken T.J. Treatment history and antimicrobial susceptibility results for Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolates from bovine respiratory disease cases submitted to the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2015. J Vet Diagn Invest. 2018 Jan;30(1):99-104. doi: 10.1177/1040638717737589. Epub 2017 Oct 15. PMID: 29034785; PMCID: PMC6504160.
6. Manishimwe R., Moncada P.M., Bugarel M., Scott H.M., Loneragan G.H. Antibiotic resistance among Escherichia coli and Salmonella isolated from dairy cattle feces in Texas. PLoS One. 2021 May 7;16 (5):e0242390. doi: 10.1371/journal.pone.0242390. PMID: 33961628; PMCID: PMC8104409.
7. Nji E., Kazibwe J., Hambridge T., Joko C.A., Larbi A.A., Damptey L.A.O., Nkansa-Gyamfi N.A., Stålsby Lundborg C., Lien T.Q. High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings. Sci Rep. 2021 Feb 9;11(1):3372. doi: 10.1038/s41598-021-82693-4. PMID: 33564047; PMCID: PMC7873077.
8. Rao H. et al. Approaches for Mitigating Microbial Biofilm-Related Drug Resistance: A Focus on Microand Nanotechnologies. Molecules (Basel, Switzerland) vol. 26,7 1870. 26 Mar. 2021, doi:10.3390/molecules26071870
9. Talavera-Gonzalez J., Talavera-Rojas M. Bacteriófagos, los virus come-bacterias: historia de dos mentes científicas. Revista Digital Universitaria. 2021. 22. 10.22201/cuaieed.16076079e.2021.22.5.9.
10. Dovnar R. I. Current trends in antibiotic resistance of pathogenic microorganisms in surgical patients. Journal of GrGMU. 2024; 2. (In Russ) URL: https://cyberleninka.ru/article/n/sovremennye-tendentsii-antibiotikoustoychivostipatogennyh-mikroorganizmov-patsientov-hirurgicheskogo-profilya (accessed: 13.06.2025).
11. Kiyanchuk M.V. Analysis of the biochemical, cultural and morphological properties of Mannheimia haemolytica isolated from the nasopharyngeal mucus of calves. Veterinary Laboratory Practice: Collection of articles and reports at the international scientific and practical conference, St. Petersburg, 17–21 April 2023. St. Petersburg: St. Petersburg State Academy of Veterinary Medicine. VVM. 2023. Pp. 29–31. (In Russ)
12. Makavchik S.A., Krotova A.L. Antibiotic resistance microorganisms of staphylococcus aureus isolated from animals. International Journal of Veterinary Medicine. 2021;(3):103-107. (In Russ.) https://doi.org/10.17238/issn2072-2419.2021.3.103
13. Makavchik S.A., Borisova M.S. Antibiotic resistance of Klebsiella pneumoniae and practical significance for veterinary medicine. Legal regulation in veterinary medicine. 2023;(1):26-30. (In Russ.) https://doi.org/10.52419/issn2782-6252.2023.1.26
14. Rodionova N.Yu., Rudenko P.An., Sotnikova E.D., Prozorovsky I.Y., Shopinskaya M.I., Krotova E.A., Semenova V.I. Sensitivity to antibiotics and phytobiotics of initiators of acute catarrhal bronchopneumonia in calves. Bulletin of the Russian University of People's Friendship. Series: Agronomy and Animal Husbandry. 2024; 2. (In Russ) URL: https://cyberleninka.ru/article/n/chuvstvitelnost-k-antibiotikam-i-fitobiotikaminitsiatorov-ostroy-kataralnoy-bronhopnevmonii-u-telyat (accessed: 13.06.2025).
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For citations:
Kiyanchuk M.V., Sukhinin A.A. Monitoring antibiotic resistance of pathogens causing bronchopneumonia in young cattle. Legal regulation in veterinary medicine. 2025;(2):55-60. (In Russ.) https://doi.org/10.52419/issn2782-6252.2025.2.55
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