Study of the influence of ankyolytic drugs on the behavior of rats and identification of the formation of withdrawal syndrome
https://doi.org/10.52419/issn2782-6252.2025.2.84
Abstract
In modern veterinary medicine, drugs with psychotropic effects are increasingly used to correct behaviour and minimize negative effects of stress factors. The aim of the study was to investigate the effect of drugs with anxiolytic activity on the behaviour of rats and to identify the addictive potential of the drug. The experiment was conducted on male white laboratory rats of Wistar line weighing 350-450 grams. Atarax was used as an anxiolytic drug. The rats were given the drug in appropriate doses for a month. During the course of the drug administration a number of ethological tests were performed in order to reveal the effect of the active substances of the drug on the behaviour of rats. After the end of the course, ethological tests were also performed to reveal the addictive potential of the drug. The rats from the experimental and control groups showed significant differences in a number of ethological tests, which indicates the effect of the drug on the social-research behaviour of rats. At the end of the course of the drug administration in the rats of the experimental group the formation of «withdrawal syndrome» wasn’t observed. Anxiolytic drug «Atarax» has a calming effect, it is possible to use the drug in animals with increased anxiety in order to relieve their psychoemotional tension. Nevertheless, when using the drug it is necessary to accurately calculate the dosage to avoid possible toxic effect and formation of addiction.
About the Authors
O. A. Dushenina
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Olga Al. Dushenina - Cand. of Biological Sciences, Docent
L. Yu. Karpenko
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Larisa Yu. Karpenko - Dr. of Biological Sciences, Prof
Ya. K. Eseneeva
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Yasmin K. Eseneeva - Student
References
1. Bragin A.V. Clinical case of using the tricyclic antidepressant amitriptyline in anticipation of a cat with interspecies aggression towards humans // Russian Veterinary Journal. 2019;1. [Electronic resource]. (in Russ) Access mode: https://cyberleninka.ru/article/n/klinichesky-sluchay-primeneniya-tritsiklicheskogoantidepressanta-amitriptilina-v-lechenii-koshki-s-mezhvidovoy-agressiey-po (date of access 06/15/2025)
2. Dushenina O.A., Karpenko L.Yu., Stopichev V.G. Distant action of acetylcholine and its toxic manifestations. Legal regulation in veterinary medicine. 2018;(4):259-262. (in Russ)
3. Karamyan A.S., Shabunin S.V., Vatnikov Y.A. Experimental activity of anxiolytic action of Sedatin in the pharmaceutical form of transbuccal film. Normative-legal regulation in veterinary medicine. 2019;4: 103-107. (in Russ) DOI 10.17238/issn2072-6023.2019.4.103
4. Polidanov M.A., Skorokhod A.A., Babichenko N.E. Reactivity and stress: haemostatic reactivity of the organism under stress. Study of the effect of stress on haemocoagulation. Modern Science. - 2020;3-1: 308-312. (in Russ)
5. Hasina E.I., Moiseenko L.I. Transport stress and its correction with anxiolytics. Agricultural Sciences and Agroindustrial Complex at the turn of the century. 2014;7. [Electronic resource]. (in Russ) Access mode: https://cyberleninka.ru/article/n/transportnyy-stress-i-ego-korrektsiya-anksiolitikami (date of access 06/15/2025)
6. Shamonina A.I. Influence of stress at transfer of cows on their productive and reproductive abilities. Zootechnical science of Belarus. 2021;56(2): 268-275. (in Russ)
Review
For citations:
Dushenina O.A., Karpenko L.Yu., Eseneeva Ya.K. Study of the influence of ankyolytic drugs on the behavior of rats and identification of the formation of withdrawal syndrome. Legal regulation in veterinary medicine. 2025;(2):84-88. (In Russ.) https://doi.org/10.52419/issn2782-6252.2025.2.84
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