Evaluation of the effectiveness of a mixture of noble gases and oxygen in the treatment of animals with signs of hypoxia in clinical conditions

On a sample of animals (cats and dogs of different genders, of different ages with different diseases, a total of 30 individuals) in a state of hypoxia, a study was conducted on the correction of this condition with a medicinal product for veterinary use "Aroxxen-vet" (Aroxxen ® -vet), which is a mixture of oxygen, argon, xenon and nitrogen gases. The patient's exposure time in the box averaged 6 hours before surgical treatment for the underlying disease. During the study, various parameters of the respiratory and cardiovascular systems, body temperature, lactate levels, and arterial blood saturation were monitored. Measurements were performed before and after therapy with Aroxxen-vet gas. Based on the data obtained, it can be concluded that the use of mixtures of gases with a high content of inert gases (argon, xenon) and oxygen helps to stabilize the indicators of the functional state of the animal, slow down the progression of the underlying disease and, in some cases, improve the estimated indicators (lactate, BDD). Thus, the use of "Aroxxen-vet" (Aroxxen ® -vet) for 6 hours in animals in a state of hypoxia has a positive effect on the condition of the body in the preoperative period, which reduces anesthetic risks in the operational and postoperative periods. The use of this drug for veterinary use is a promising direction in the respiratory support of animals with a serious condition, increasing the effectiveness of pathogenetic therapy.

1. Ananyev V.N. Effect of inert gases on oxygen absorption in a confined space under normobaric conditions. Proc. of the IX All-Arm. scientific-practical. conf. with international participation "Barotherapy in the complex treatment of the wounded, sick, and affected". SPb.; 2015: p. 80. (in Russ)

2. Dovgusha V.V, Achkasov E.E., Dovgusha L.V., Roshchin I.N. Biomedical properties of xenon and other non-polar gases. Marine Medical Journal. 2016; 2-3: 16-25. (in Russ)

3. Nechayev A.Yu. On the possibility of correcting respiratory disorders in animals using general anesthetics and sedatives. Proc. of the 54th scientific conference of young scientists and students: SPbGAVM. SPb; 2000: 65–66. (in Russ)

4. Betschart-Wolfensberger R., Stekolnikov A.A., Plemyashov K.V., Nechaev A.Yu. General anesthesia and euthanasia in veterinary medicine: textbook. Manual. SPb.: Prospect nauki; 2017:376 p. (in Russ)

5. Report on the research work "Study of the toxic properties, local irritant effect and pharmacological safety of the artificial gas mixture IGS No. 1 (O2 + Ar + Xe) on ferrets with repeated use with a delayed observation period", UDC 615.076.9: 615.458, study code: 2.58/20, JSC NPO Dom Pharmatsii. (in Russ)

6. Report on the research work "Study of the protective efficacy of a normobaric breathing gas mixture with an increased content of inert gases in a model of ischemic stroke in rabbits", based on the Federal State Budgetary Institution "Research Institute of Influenza named after A.A. Smorodintsev Research Institute of the Ministry of Health of the Russian Federation, study no. NIR-LHT-SA-009/2021. (in Russ)

7. Report on the research work "Evaluation of the therapeutic efficacy of artificial gas mixtures IGS No. 1 (O2 + Ar + Xe) and IGS No. 2k (O2 + N2) in a model of ischemic brain injury in rats", UDC 615.076.9: 615.458, study code: 4.28/20, JSC NPO Dom Pharmatsii. (in Russ)

8. Pavlov B.N., Soldatov P.E., Dyachenko A.I. Survival of laboratory animals in argon-containing hypoxic environments. Aviation and environmental medicine. 1998; 32(4):33-37. (in Russ)

9. Pavlov B.N., Soldatov P.E., Dyachenko A.I. Survival of laboratory animals in argon-containing hypoxic environments. Aviation and Environmental Medicine. 1998; 32(4):33–37. (in Russ)

10. Shelby A.M., McCune C.M. Small animal anesthesia techniques. Wiley Blackwell; 2022:435 p. (in Russ)