The efficiency of recombinant bovine alpha and gamma interferon for prevention of mastitis in cows
Abstract
The article presents the results of studying the efficiency of the bovine recombinant a-and y-interferons application in the prevention of mastitis in cows, their influence on the immune-biochemical parameters of blood. The experiments were carried out on clinically healthy lactating cows. The animals of the first group (n=16) were not treated with drugs, they served as a control one; the cows of the second group (n=16) from the first day after calving were injected monthly intramuscularly with an interval of 48 hours with bovine recombinant α - and γ-interferons of 2.5 ml. Evaluation of the efficiency of the use of bovine recombinant α-and γ-interferons was carried out three times a week using diagnostic studies of milk with 2% solution of the mast test. The studies were conducted for 4 months. As a result of the tests, it was found that the developed method prevents the incidence of mastitis in 37.5% of animals, normalizes the immune status of the cows both due to humoral (BASK, CARESSES, CEC, General immunoglobulins) and cellular link (FAL, lymphocytes), increases the level of antioxidant protection (GPO, catalase), reduces the intensity of free radical oxidation of lipids (MDA).
About the Authors
N. T. Klimov
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
V. I. Zimnikov
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
D. A. Erin
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
A. V. Pashentsev
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
G. G. Chusova
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
T. G. Ermolova
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
L. N. Kashirina
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
I. F. Klementyeva
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
E. V. Tyurina
All-Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy of Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
References
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Review
For citations:
Klimov N.T., Zimnikov V.I., Erin D.A., Pashentsev A.V., Chusova G.G., Ermolova T.G., Kashirina L.N., Klementyeva I.F., Tyurina E.V. The efficiency of recombinant bovine alpha and gamma interferon for prevention of mastitis in cows. Legal regulation in veterinary medicine. 2018;(3):82-84. (In Russ.)
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