Study of the local irritive effect of the preparation Tildoks on the skin

Abstract

The purpose of the research was to study the local irritating effect of the drug Tildox on the skin. Tildox is a complex antibiotic in the form of a powder. Tildox contains the active ingredients doxycycline hyclate - 100 mg and tylosin tartrate - 100 mg in 1 g of the drug and excipients.
In the study 20 New Zealand White rabbits weighing 3.2 - 4.1 kg were used. Prior to testing, rabbits were shorn in 10 x 15 cm patches on both sides of the back. Animals were divided into 2 groups of 10 animals each. Rabbits of the first group were given applications using a 10% aqueous solution of the antibiotic, rabbits of the 2nd group were treated with a 50% aqueous solution of the drug. Applications were carried out 1 time per day for 14 days at a dose of 0.5 ml per animal. Aqueous solutions of antibiotics were applied to the right side of the rabbits, the left side of the rabbits served as a control: applications with water were carried out in this place. The exposure time each day was 4 hours.
As a result of the research, it was found that after repeated application of the drug Tildox in 10% and 50% concentrations by applications 1 time per day for 14 days at a dose of 0.5 ml, no changes in the skin were observed per animal.