The article analyzes the implementation of legislative requirements in the field of treatment of animals for their use in cultural and entertainment events. Data are provided for the Russian Federation on the number of controlled objects in this area. Data on objects controlled by the North-West Interregional Directorate of Rosselkhoznadzor were analyzed. It is determined by what criteria and what categories of risk of harm to legally protected values include objects that are used by controlled persons when keeping and using animals for cultural and entertainment purposes. The procedure for obtaining a license to carry out the type of activity under study is considered. A statistical analysis was carried out on the qualitative and quantitative composition of controlled objects for a number of subjects belonging to the North-West region. An analysis of the powers of the Federal Service to carry out federal state veterinary control (supervision) on compliance or non-compliance by a controlled person with mandatory requirements is carried out. The range of preventive and control measures, their scope and responsibility for violation of the law have been determined.

The problem of organizing veterinary activities in the territories of horticultural, horticultural and other non-profit associations of citizens needs attention. Many land owners keep agricultural, pet companions. They often do not comply with the norms of legislation in the field of veterinary medicine, there is a concealment of facts and violation of the rules of maintenance, animal diseases, we see ignorance of the owners about the signs of manifestation, lack of awareness of the threats of a particular disease. At the same time, there is no centralized accounting of animals kept on the territory of the non-commercial gardening, as there is no work to perform veterinary knowledge. It is necessary to plan veterinary and educational work: organize meetings with representatives of the non-commercial gardening administration, animal owners, and present information material in the form of posters and leaflets on the ground. It is necessary to place sections on the electronic resources of the animal disease control station, non-commercial gardening containing in an accessible form the information on the maintenance, feeding of agricultural and domestic unproductive animals, carrying out antiepizootic measures, it is advisable to provide regulatory and legal information, inform in an accessible form about the need for veternary and sanitary examination of products obtained on the territory of the non-commercial gardening. The issue of registration and vaccination of animals can also be solved by organizing field events of representatives of the district animal disease control station in the non-commercial gardening. It seems necessary to change the approach to the list of acceptable ways of using land plots belonging to the category of agricultural land with an established type of permitted use for horticulture, so that among them there is the maintenance of farm animals.

The article discusses the specific requirements for hunting products, which are enshrined in veterinary legislation, including veterinary rules. The authors analyzed federal legislation regarding the establishment of requirements for hunting products and the need to conduct a veterinary and sanitary expertise of hunted animals. The article states that the use of hunting products is possible only after the necessary measures have been taken, which include inspection of the carcass by the hunter or the responsible person of the hunting enterprise, taking biomaterial for veterinary and sanitary expertise and obtaining a conclusion.

The economic efficiency of industrial animal husbandry in modern conditions provides not only for an increase in productivity, but also for maintaining the optimal level of basic physiological functions, including reproductive ones. The successful implementation of the task of preserving reproductive function is hindered by diseases of females of various etiologies that negatively affect their reproductive ability. One of these diseases is genital mycoplasmosis of cattle, which has a significant prevalence on dairy farms, both abroad and in the Russian Federation. The effectiveness of therapy for this disease largely depends on the initial state of the immune system. The objective of our research was to study the therapeutic efficacy and effect on the immunoglobulin composition of blood serum and vaginal secretions of patients with genital mycoplasmosis of cows of the use of the antibiotic tulathromycin and its combination with the immunomodulator thymalin. The results obtained demonstrated that the use of tulatromycin for treatment leads to the recovery of 75% of experimental animals and ensures the restoration of the immunoglobulin profile of vaginal secretions, whereas the immunodeficiency state observed in blood serum is only partially restored. The combination of an antibiotic and an immunomodulator ensured the recovery of all experimental animals and the restoration of the immunological characteristics of blood serum and vaginal secretions to the level of healthy cows.

One of the important tasks of veterinary medicine in the Russian Federation is the implementation of measures to prevent and eliminate infectious animal diseases[2]. Animal rabies is a zoonotic transboundary disease. It is characterized by natural focality, and wild carnivores, in particular the fox, are considered a reservoir of the rabies pathogen. Since the end of the twentieth century, oral rabies vaccines have been used to prevent rabies in Western Europe and the United States [1,3].

This article presents the results of research work in 2003-2009. to create a buffer zone against animal rabies on the border with Finland by oral vaccination of wild carnivores in the Leningrad region, the Republic of Karelia. Live vaccines were used in the work: "FUCHSORAL" (Germany) and domestic ones - "SINRAB" (FGBU "ARRIAH, Vladimir) and its analogue - the vaccine "ORALRABIVAK" produced by OJSC "PZB" (Pokrov).

In the Leningrad region and the Republic of Karelia in 2003, the FUCHSORAL vaccine (Germany) was used once, and in subsequent years, double annual vaccination was carried out with domestic vaccines. In Finland, people were constantly vaccinated with the oral rabies vaccine “FUCHSORAL” (Germany), from the “SAD B19” strain [4]

We carried out annual 2-fold vaccination (in spring and autumn) of wild carnivores, in accordance with the instructions for use of vaccines, at air temperatures from +2 to +8 C in a zone 50-80 km wide from the border for 6 years. The number of blood serum samples containing a level of rabies virus-neutralizing antibodies sufficient to protect against rabies in the Republic of Karelia increased from 0% to 80%, and in the Leningrad region. from 0% to 70%.

As a result of the implementation of planned work in the period 2003-2009. to prevent rabies among wild carnivores in the Leningrad region and the Republic of Karelia, epizootic freedom from rabies was achieved, satisfying the neighboring country.

Rapidly developing antibiotic resistance limits the capabilities of veterinary specialists and doctors in the fight against infectious diseases. Effective diagnosis and continuous improvement in the field of antimicrobial therapy is the main approach in the treatment and prevention of bacterial infections. According to available data, bacteria are able to develop resistance in 2-3 years, while it takes an average of 5 years to develop and test a new antimicrobial drug. In our study, bacteriological examination of samples of pathological material from cows from 10 livestock farms in different districts of the Leningrad region was carried out, followed by determination of the sensitivity of isolated crops to antibiotics. In this study, 84 samples from cows were selected and examined and 115 cultures of microorganisms were isolated. As a result of the bacteriological study of the pathological material from cows, 9 groups and types of pathogenic and opportunistic microorganisms were identified. The main proportion is detected on staphylococci – 35.7%, mainly Staphylococcus aureus, epidermal staphylococcus and citrus staphylococcus. Escherichia coli (23.5%) and Proteus vulgaris (20.9%) were among the microorganisms in terms of frequency of occurrence. Most of the isolated cultures had average sensitivity to gentamicin, enrofloxacin, ciprofloxacin, ceftriaxone, cefepim, cefotaxime, neomecin; resistant to doxycycline, amoxicillin, levofloxacin, colistin, doxycycline, streptomycin, tylosin, tetracycline.

This article presents the results of a study of the toxicity and antiparasitic effects of conditioners - broad-spectrum adaptogens produced by a domestic manufacturer in conditions of aquarium cultivation of ornamental fish. It has been established that all 4 presented solutions have low toxicity and contribute to the complete ridding of fish from ectoparasites of different systematic positions. The possibility of import substitution in the modern economic realities of the ornamental fish farming market of the Russian Federation is considered.

One of the first signs of theileriosis is asymmetrical enlargement of the lumbar, suprathoracic and patellar lymph nodes. As a result of studies of sick animals in the Ismayilli region of Azerbaijan, theileriosis was identified. Microscopic examination of blood smears and fluid taken from the lymph nodes of sick animals in erythrocytes and outside erythrocytes reveals various forms of theileria. During the incubation period on the 2-3rd day of the disease, “pomegranate bodies” of the pathogen of various shapes, 8-20 microns in size (μm), which consist of a large number (40-50 or more) appear in the enlarged lumbar, suprathoracic and patellar lymph nodes.dark red nuclei and blue colored plasma.

This article presents the results of research on the effectiveness of preventive and therapeutic measures for mastitis in cattle. In modern conditions, in the farms of the Smolensk region, the disease of large cattle (cows) with mastitis is an urgent problem. In this regard, the subject of our research was the work on the search and application of new most effective means for the prevention and treatment of breast disease in lactating cows. The object of research was cattle. The work was carried out in the conditions of a farm in the Smolensk region. In order to implement a comprehensive approach to the diagnosis, prevention and therapy of cattle in the household, the situation was first studied by suit.

The article considers etiological factors, clinical manifestations, laboratory and instrumental methods for diagnosing kidney pathology, which requires the use of antibacterial drugs – pyelonephritis. However, this pathology can be difficult to diagnose and not every antibacterial drug is suitable for its treatment. The main ways of kidney damage by bacterial infection in small domestic animals are ascending infection and hematogenous introduction, when pathogenic microorganisms enter the kidneys along with the bloodstream. The article provides predisposing factors leading to the development of pyelonephritis. Pyelonephritis has several types of course. The acute form of the disease is most easily diagnosed due to the vivid clinical signs and pronounced changes in blood, urine, and kidney sonography tests. Whereas the chronic form and latent course may be overlooked due to the nonspecific clinical picture. In the treatment of pyelonephritis, the occurrence of antibiotic resistance in bacteria can be fatal for the patient, because if it is impossible to eliminate infection in the kidneys, the development of renal failure is inevitable, leading to all manifestations of uremia, anemia and other changes that occur with impaired renal function. To prevent the development of antibiotic resistance, it is extremely important to make a final diagnosis through bacteriological urine culture, but pyelonephritis is a pathology that requires a comprehensive diagnostic approach and, if suspected, it is advisable to start etiological treatment immediately, correctly choosing an antibiotic. Not every antibacterial drug is suitable for the treatment of pyelonephritis. For example, one of the first-line drugs of choice in the treatment of urinary tract infection (UTI), amoxicillin with clavulanic acid does not penetrate the renal parenchyma. The group of choice for the treatment of bacterial inflammation of the kidneys are fluoroquinolones, but not every drug from this group is suitable for treatment in animals and there are certain restrictions in their use in the case of puppies, kittens, as well as in cats as a species, therefore, the selection of an antibiotic should be carried out individually in each clinical case, taking into account the pharmacokinetics and pharmacodynamics of the drug, the result of urine sampling and other studies, as well as the physiological characteristics of the patient.

According to a number of authors, a sharp change in the type of feeding and the effects of stress factors in piglets after weaning lead to disorders not only of metabolism, but also of membrane digestion, which further contributes to a decrease in body resistance and the occurrence of various diseases of the digestive organs.

In the course of our study, it was found that the use of probiotic strains Enterococcus faecium L-3 and Enterococcus faecium 1-35 for the treatment of gastroenteritis in piglets during weaning had a similar effect on restoring intestinal enzymatic activity. In piglets that were not treated with probiotics (control 1), enzymatic activity in the digestive tract was only partially normalized during the study. We also evaluated some parameters of the ongoing metabolic processes in the body of weaning piglets by studying the biochemical blood parameters of the experimental groups after prescribing the probiotic strain Enterococcus faecium L-3 (experiment 1) and Enterococcus faecium 1-35 (experiment 2) comparing them with those of the control group of animals.

Gastroeintestinal diseases are one of the most common groups of diseases among small domestic animals. The gastro-intestinal tract includes the oral cavity, pharynx, esophagus, stomach, pancreas, small intestine and large intestine. General signs of digestive system disorders in cats with diseases of the digestive tract are vomiting, regurgitation, capricious appetite, as well as various defecation disorders: diarrhea, coprostasis, various inclusions in feces (blood, mucus). Diseases of the gastrointestinal tract of a chronic nature often involve the manifestation of symptoms on an ongoing basis or are recur-rent in nature. Chronic gastritis, enteropathy, pancreatitis require specialized diets that normalize the functioning of the digestive tract and help improve digestive function. These therapeutic complete diets are presented in ready-made feeds in dry (pellets) and wet (pates, pouches) variations from many manufacturers of industrial feeds. Dietary therapy is required long-term or lifelong; during remission it is the basis in the treatment of chronic patients. The compositions of these diets take into account the physiological and specific needs of the animal, and are also developed on the basis of easily digestible ingredients and a reduced amount of fat, but completely replenishing the required amount of calories.

The relevance of introducing pharmacoeconomic studies into veterinary medicine is undeniable, since they allow us to assess the cost and effectiveness of various medications and manipulations associated with their use, which helps veterinary specialists choose the most optimal treatment methods and prevent inappropriate or unnecessarily expensive con-sumption of medical resources. Such an economic assessment makes it possible to reduce the costs of veterinary care and ensure the availability of high-quality medical care for all categories of animals.

The main problem of using existing pharmacoeconomic methods in veterinary medicine is the actual absence or impossibility of relevant assessment of certain characteristics (for example, indicators of the “benefit” of treatment for compaion animals; the integral indicator QALY - “years of quality life saved,” etc.), which allows us to consider analysis and generalization of methodological features of the implementation of pharmacoeconomic models in veterinary medicine is an urgent task.

To achieve this goal, the scientific literature was analyzed (including bibliographic peer-reviewed databases such as Scopus, WoS, Pubmed, elibrary) with a further selection of relevant and current sources (published over the last 10 years) with their subsequent stratification according to the principle of applicability of the described methodological approaches for veterinary medicine, which were generalized and systematized.

As a result of the analysis, it was determined that in veterinary medicine it is permissible to use analytical, statistical and simulation mathematical models.

Pharmacoeconomic studies play an important role in assessing the relationship between treatment costs and outcomes. This allows you to evaluate the effectiveness of using a particular drug, conduct a comparative analysis of various treatment methods and make informed decisions about choosing the most suitable drug. In this way, pharmacoeconomic studies help improve the quality of veterinary treatment and ensure maximum benefit to the owner.

In the modern livestock sector, the domestic industry of the North-West region, cases of poisoning of animals on farms and large complexes are increasingly occurring. This is primarily due to the intensive use of various synthetic modulators, growth stimulants, fertilizers in the agronomic industry and the excessive use of antibiotics, hormones and other veterinary drugs in animal husbandry.

Pharmacological screening of oral detoxification agents with differentiation of target pathologies is a promising direction in the development of domestic animal husbandry. A reasonable choice of sorbents in each individual case of poisoning allows you to quickly achieve a therapeutic effect, reduce the toxic load on the animal’s body, which further ensures sustainable productivity and high quality products. This work highlights the results of some studies on the functional activity of the most common enterosorbents in relation to toxins of various natures.

Based on the results of the study, it was noted that with an increase in pH from 2.0 (rennet model) to 7.5 (analogue of the distal small intestine), a release of part of the indicator substance from the pores of the sorbent (desorption) is observed, which reduces its absolute sorption effect [5] . The lowest desorption value was shown by atoxyl (8.5%) and phytopos (9.0%). That is why these drugs are the most effective oral detoxification agents for toxins with a molecular weight close to methylene blue.

The maximum adsorption effect for various poisonings in animals can be achieved by using sorbing agents that are highly selective for a particular toxin. Research on the choice of oral detoxification agents with differentiation of target pathologies significantly expands the database on existing sorbents, makes it possible to prevent and treat poisonings of various types more effectively, and provides opportunities for the combined use of various adsorbent substances.

L-carnitine is a vitamin-like substance that plays an important role in the transport of fatty acids and their further use as an energy source. Most studies have identified beneficial effects of using L-carnitine for preventive and therapeutic purposes. The series of publications reviewed is devoted to the study of the results of the use of L-carnitine in metabolic disorders, diseases of various organs, organ systems, the central nervous system, as well as to elucidate the possible reasons for the decrease in the level of L-carnitine in the body. To date, L-carnitine is used in the Russian Federation only in the form of a feed additive; the purpose of our study was to study L-carnitine in the form of an injection solution. Toxicity studies were conducted on outbred rats in October 2021 in the vivarium of the St. Petersburg State University of Veterinary Medicine. The study involved females weighing 190-210 grams. When studying subchronic toxicity when administered intra-muscularly, L-carnitine was administered at 2 dose levels. 1/5 and 1/10 of the maximum tolerated dose in acute toxicity studies. In this regard, three groups of animals were formed. The first experimental group (n=10) was administered the drug intramuscularly at a dose of 0.08 mg/kg, the second group (n=10) at a dose of 0.04 mg/kg. The control group (n=10) was intramuscularly injected with a 0.09% sodium chloride solution at a dose of 0.08 mg/kg. The study was carried out over 42 days. Biological material samples were taken from 5 animals from each group the next day after the end of the drug administration (day 43), and 10 days after the last drug administration (day 53). The results of the study showed that dosages of 1/5 and 1/10 of the maximum tolerated do not cause external signs of toxicosis and death in rats. No significant changes were found in the biochemical parameters of the blood of animals in the experimental and control groups.

The purpose of our research was to study the effect of Tildox AVZ on rat blood counts in a subchronic experiment. Tildox is a complex antibiotic in powder form. One gram of drug contains doxycycline hyclate – 100 mg and tylosin tartrate - 100 mg as active ingredients, sodium benzoate and sucrose as auxiliary substances. The experiment lasted 90 days. The study was conducted on 150 Wistar rats (75 males and 75 females). The body weight of the animals was 190-230 g. During the experiment 5 groups of 30 animals (15 males and 15 females) were formed, three of them were experimental groups, one - control and one – intact. Of the 150 rats involved in the experiment after its completion 100 individuals (50 males and 50 females) were killed for pathomorphological studies of internal organs.

To identify the ability to recover and the appearance of resistance to toxic effects the remaining 50 animals (5 males and 5 females from each group) were monitored for 28 days after the experiment.

An aqueous solution of the test sample of the drug was administered daily intragastrically using an atraumatic metal probe. The drug was administered to the first experimental group at a dose of 70 mg / kg, the second group - 265 mg / kg, the third group - at a dose of 1000 mg / kg of animal body weight. The control group was in equal conditions and received intragastric saline solution. Intact animals served as a reference. It was found that Tildox AVZ administered intragastrically at doses of 265 and 1000 mg / kg 1 time per day for 90 days has an effect on clinical and biochemical blood parameters. The drug administered at a dose of 70 mg / kg does not cause changes in blood parameters. However when examining the blood of rats 28 days after the recovery period there were no significant changes in clinical and biochemical parameters compared with the control and intact groups.

From this it can be concluded that all blood changes had a dose-dependent effect and after stopping the use of the drug the body recovered which indicates the reversibility of the caused shifts in the blood picture.

The introduction of new technologies for keeping and feeding poultry, shortening the growing time of modern poultry crosses, often lead to various stress conditions, which makes them highly sensitive to diseases of various etiologies, due to an insufficiently formed immune system. In most cases, this manifests itself in the form of gastrointestinal diseases and, as a result, an increase in poultry mortality. Currently, this problem is being solved by introducing feed additives into diets that contribute to increasing natural resistance and positively affect metabolic processes in general. One of these is the feed additive Reasil® Humic Health, which improves the condition of the digestive tract, which directly affects the acceleration of growth and development of the body, an increase in average daily weight gain, and obtaining safe meat products from broilers.

The object of the study was a control and experimental group of 21-day-old Cobb-500 cross broilers, with 18,000 heads each. 

The broilers of the control group received the basic diet. In addition, Reasil® Humic Health feed additive at a dose of 2 g/ kg of feed was included in the main diet of the poultry of the experimental group. The selection of poultry for control slaughter at the ages of 22, 36 and 41 days, 60 individuals from each group, was carried out by random sampling. 

Thus, it can be concluded that Reasil® Human Health had a positive effect on the dynamics of weight and organometric parameters in broilers of the experimental group: the mass of the muscular stomach - by 11.4%, intestines - by 12% and liver - by 8% was higher compared with intact poultry.

This article presents a review of the literature and the results of our own research on the use of glucose-fructose syrup as a substitute for substandard honey and crystalline sugar in the diet of honey bees. The results of research on the search for feed products similar in properties to the natural feeds of honeybees are described, the characteristics of honey of different origins used for forage purposes are given, an idea of its quality and effect on the body of honeybees is given. Based on the conducted research, the authors conclude that in order to maintain optimal health, honey bees need to introduce new industrial products into beekeeping technology, in particular glucose-fructose syrups similar in sugar composition to nectar honey, in order to replace honeydew and feed from crystalline dietary sugar in the diet. The obtained materials can be used as a reference material for continuing research on the nutritional hygiene of honey bees, as well as in scientific activities and in practical beekeeping

In our country, a linear assessment of the exterior of animals is becoming increasingly widespread, which allows us to objectively assess the influence of the producer bull on the change in the most important exterior features that ensure the se-verity of the dairy type while maintaining high productivity and intensity of use in the herd. This ensures the ranking of animals by body type and helps to accelerate the genetic progress of productivity. In this regard, the introduction of a linear assessment of the daughters of breeding bulls in the herd of a breeding plant is relevant. We conducted research aimed at studying and analyzing the signs of a linear description of the exterior of the first-calf cows of the daughters of Holstein bulls and identifying the most common exterior flaws in one of the breeding plants of the Kirov region. The analysis of the data showed that the evaluated first-calf cows of different origins are characterized by exterior features: average height, body of medium depth, strong physique, pronounced dairy type. The most common disadvantages of the exterior of the examined heifer cows are: interception of the shoulder blades (25.6%), asymmetry of the udder lobes (23.0%), weak headstock (15.4%).

Chicken egg is a valuable dietary product and is often included in the daily human diet. In recent years, the demand of the population of our country for chicken eggs has increased and the requirements for the quality of table eggs of different categories have increased. In the trade network of St. Petersburg sells chicken table eggs of commodity categories of different manufacturers, among which quite often there is an egg, which by some indicators does not meet the requirements of regulatory documents. In this connection, a comparative analysis of commodity properties of hen's eggs of large poultry farms of the Leningrad region, selling their products in different retail chains of St. Petersburg was carried out. For the study was selected 10 packages of table chicken eggs 10 pieces per package of the following categories: selected, 1 and 2. Comparative analysis of eggs was carried out by their weight (one and ten pieces), presence of contamination, defects of egg shell and its integrity (fight), calculated shape index.

According to the conducted research it was established that the greatest deviations from the requirements of GOST on the weight of eggs and the presence of defects were established in the batch of eggs of the enterprise №1, sold in the retail network "Lenta". The analysis of the weight of eggs of all categories of poultry enterprise No. 2 corresponds to the permissible limit of GOST. In spite of single cases of non-compliance of egg weight to the trade categories indicated on the pack-age, the weight of 10 pcs. corresponded to the GOST requirements. 

According to the data of the conducted research it is established that the greatest deviations from the requirements of GOST on egg weight and the presence of defects were established in the batch of eggs of enterprise No.1, sold in the retail network "Lenta". The analysis of the weight of eggs of all categories of poultry enterprise No. 2 corresponds to the permissible limit of GOST. In spite of single cases of non-compliance of egg weight to the trade categories indicated on the pack-age, the weight of 10 pcs. corresponded to the GOST requirements. 

The table eggs produced by enterprise No.1 are sold in the trade network "Lenta" and "Magnit" with signs of contami-nation (31-36%) and breakage (3-9%), as well as with shell defects. (3-9%). For poultry farm No.2 the noted defects made up 17-22%, 1-6% and 1-4% respectively. Enterprise No.1 sells table eggs of different shapes with insignificant deviations from the recommended norm with egg shape index of 72-80%. At enterprise No.2 this index was 77-80%. That fully meets the normative requirements. It was found that eggs of category C2 of both producers to a greater extent met the requirements of normative documents and can be recommended to consumers of St. Petersburg.

The activities of various terrorist organizations, illegal migration and transportation of explosives and narcotic drugs across borders require enhanced protection and protection of Russian interests. The olfactory capabilities of dogs, which have a much greater potential for obtaining information about the chemical composition of not only the environment, but also transported goods, are an important factor in protecting the borders of the state. The presence of well-trained dogs at checkpoints allows not only to better fulfill assigned security and search tasks, but also to increase their psychological confidence. A scientifically justified and well-organized system of keeping, feeding and operating service dogs is the most important condition for their effective and long-term use in economic activity.

Ophthalmopathy associated with parneoplastic syndrome is a poorly studied pathology of the dogs eye. They occur as a result of the malignant neoplasm’s systematic exposure on the animal's body. They appear in the form of non-specific clinical signs. Main objective of the study – to study the pathomorphological changes in the dog’s eyes with malignant neo-plasms. The material for the study were 30 eyeballs enucleated in dogs in the terminal stage of cancer. Autopsy material obtained from animals was subjected to standard histological processing. As a result of histological studies, pathomorphological changes in eyeball structures associated with Patnaik G2 and G3 mastocytomas (28.6% of cases), liver and kidney carcinomas (28.6%), lymphoma (28.6%) and spleen hemangiosarcoma (14.2%) were revealed in 46.7% of cases. The main histopathological changes were thickening of the iris due to inflammatory cellular infiltration (57.1%) and vasodilation of blood vessels (42.9%), the presence of fibrinous hemorrhagic exudate in the anterior chamber of the eye (28.6%), edema and inflammatory infiltration of the vascular membrane proper (42.9%), thinning, loss of layering and weak retinal atrophy (42.9%). The revealed histological changes indicate the predominant involvement in the pathological process of the vascular membrane of the eye with a violation of the hematophthalmic barrier, as the main pathogenetic mechanism for the development of endogenous uveitis against the background of malignant neoplasm in the animal body.

Chronic liver failure is characterized by significant impairment of liver function due to exposure to a damaging factor for a long time. In cats, one of the most common liver diseases is lipidosis, or fatty liver dystrophy – a condition in which there is an excessive accumulation of fats in hepatocytes caused by a complex of metabolic disorders (for example, obesity, impaired energy metabolism). Diagnosis and prognosis of the course of liver diseases in cats can cause difficulties due to a number of factors, therefore, it is relevant to search and evaluate available and minimally invasive diagnostic methods for early detection and treatment strategy planning. Leukocyte indices can be one of these mechanisms. They can be useful in the diagnosis of liver diseases, as they reflect the degree of neuro-humoral reactivity and the body's response to various stimuli, in particular, to a decrease in detoxification function of the liver. The purpose of the presented study was to evaluate and compare the indicators of leukocyte indices in cats with chronic degenerative liver disease using the example of liver lipidosis with the corresponding indicators of clinically healthy animals. significant deviations of leukocyte indices associated with the level of lymphocytes and neutrophils were revealed, which allow a comprehensive assessment of leukogram parameters. The introduction and use of these indicators in veterinary practice will make it possible to better predict the course of the disease and better develop a treatment strategy. It should be noted that in order to more accurately determine the diagnostic significance and the possibility of determining forecasts, it is necessary to increase the number of animal samples with an assessment of indicators in dynamics.

Currently, there are known pig breeds that are characterized by a high rate of growth and development, precocity, fertility, individual structural features, high productivity and economic profitability. The study and breeding of new pig breeds helps to thoroughly analyze the data obtained in comparative, species, age aspects with similar types of farm animals. This fact helps to make a reliable assessment of all economic factors, as well as to analyze the quality of products received from the pig industry. The study was conducted at the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine. Cadaveric material for the study was delivered to the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine from the pig breeding complex of the Leningrad Region. To achieve this task, traditional morphological research methods were used, namely: fine anatomical dissection with injection of latex vessels, photographing, vasorentgenography with injection of lead meerkat, morphometry in the "RadiAnt" program. The largest main vessels diverting blood from the pig's stomach are the splenic, left and right gastric veins. Ultimately, they are syntopically connected to the small omentum, passing between the leaves of which they open into the portal vein of the liver. The branch of the right gastric vein branches along the loose type, and the splenic and left gastric veins branch along the main one. When conducting a comparative analysis of the morphometric characteristics of the diameter, the splenic vein will prevail over the left and right gastric veins. The results of the study can be used by veterinary specialists, in particular surgeons, to establish operative access to the stomach of pigs.

The material for the study was fragments of the wall of the duodenum, jejunum and ileum obtained from five piglets at the age of 41 days. The selected tissue samples were fixed during the day in a 10.0% solution of neutral formalin. Their further processing in order to obtain histological sections was carried out according to a generally accepted method. The obtained histological sections were stained with hematoxylin and eosin and according to Van Gieson. All morphometric data obtained were subjected to statistical processing.

It was found that in the studied animals, the small intestine is arranged in accordance with the general plan of structure peculiar to mammals. Its wall is formed by the mucous membrane, submucosal base, as well as muscle and serous mem-branes. The epithelial layer of the mucous membrane of the small intestine is represented by a single-layer prismatic epithelium, which is a highly dynamic structure that quickly reacts to changing loads due to the high rate of cell renewal. The bulk of the epithelial layer is represented by edged enterocytes (about 90.0% of the entire cell population). In addition to them, goblet-shaped, endocrine, Panethovian, proliferating and stem cells take part in the formation of the epithelial lining of the small intestine.

Relevance. Previously, we conducted comparative morphometric studies of skin samples from different topographic sites in adult cows obtained in winter. At the same time, morphological features of the skin of different topographic areas were established. In this paper, the purpose of our study was to conduct comparative morphometric studies of the skin of different topographic areas in calves.

Methods. Morphometric studies of histological preparations were carried out at the Department of Pathological Anatomy and Forensic Veterinary Medicine and at the Department of Biology, Ecology and Histology. Morphometric studies of histological preparations were used to study the thickness of the dermis proper, as well as bundles of collagen fibers of the mesh layer of the dermis. The research results were statistically processed using the "Biostat" program.

Results. Morphological features of the skin of different topographic areas in calves have been established, manifested by different thicknesses of skin layers and bundles of collagen fibers of the dermis. The morphometry performed made it possible to supplement the data on the morphological structure of the skin of cattle and can also be used in the study of morpho- and pathogenesis of skin diseases.

The first measures of state power to prevent epizootics in Russia are considered; the regulatory legal acts issued at the end of the 17th - 18th centuries, regulating sanitary and quarantine measures, are analyzed; previously unpublished legal acts of the Russian state on combating animal diseases are published.

The article is devoted to epizootics of anthrax, which has been known to mankind since ancient times and caused enormous damage, causing death of animals and people. Russian chronicle sources, starting from the 10th century, testify about devastating epidemics, the nature of which was unknown at that time. Scientists first discovered anthrax bacilli in the blood of sick animals in 1855 and proved their role in causing the disease in different species of animals and humans. The research of Lev Semyonovich Tsenkovsky on obtaining the first Russian anthrax vaccine and his work on developing the foundations of bacteriology in Russia are discussed.