The comparative analysis of the actual domestic and foreign documentation in the sphere of safety of mollusks against parasitic diseases is carried out. As a result, it was found that the international technical regulations of the EAEU are the most comprehensive and complete set of rules and requirements governing the problems of turnover of shellfish and products of their processing, but these documents do not sufficiently cover the issues of parasitological safety, and a small list of controlled pathogens is presented. In the national legislation of Russia and other EAEU members there are no rules for food of terrestrial mollusks, and a narrow list of dangerous for human parasites and the species of mollusks are also given. In addition, there is no common information about the methods of disinfection. On the contrary, the legislation of the Republic of Belarus has integrity in the sphere of hydrobiont turnover, a document regulating the turnover of terrestrial mollusks has been developed, and the conditions for neutralization of products are uniform. In this regard, we believe that there is a need to improve the legislation in force in the territory of the Russian Federation on the regulation of parasitological safety of shellfish and products of their processing, in particular, the adoption of uniform, more stringent requirements for disinfection, expansion of the list of species of mollusks and dangerous for human parasites. Proposed to expand the list and to insert Echinostoma, Anisakis (for Bivalvia) and Angiostrongylus. According the expanded list of pathogens is need to edit methods of research and identification of parasites. Among other things, it is advisable to bring the regimes and conditions of disinfection of products contaminated with parasites (TR CU 040/2016) to more stringent, such as national (SanPiN 3.2.3215-14) requirements.

The article tells about the overview of the status and trends for further use of genetically modified organisms (GMOs) in the world and the Russian Federation for the last years. On the example countries where is growing of genetically modified crops (GM-crops) was situation on the use of sowing areas for GM-crops is analyzed. The list of the most popular GM -crops in agriculture is analyzed. According to Federal Service for Oversight of Consumer Protection and Welfare within the framework of postmarketing monitoring, the results of GMO detection in food products in the territory of the Russian Federation for 2013-2016 have been analyzed. According on the data from the RASFF portal, the food products imported into the territory of the European Union of detection of GMOs for 2013-2016 have been analyzed. The article tells about devoted to a comparative assessment of the legislative base of the European Union and the Russian Federation concerning the standards of quality and use of GM-products.

The article presents the results of the study obtained by analyzing and mathematical calculations of the data obtained during the research of the materials of the 4 administrative districts of St. Petersburg (Admiralty, Moscow, Frunze, Central). The results obtained during the normalization of labor of veterinary specialists of the Department of veterinary and sanitary measures with ranking by the type of activities carried out by enterprises became the material for the calculation of the labor productivity coefficient at the enterprises of various activities. (Wholesale enterprises, processing enterprises, wholesale and retail enterprises). The results of the calculation of the increasing coefficient of labor productivity allowed to scientifically justify the degree of operational work load on the veterinary specialist, depending on the type of activity of the serviced enterprise, which in turn provides the scientific basis for planning in veterinary medicine.

The purpose of this study to evaluate diagnostic efficiency of isolated rabies antigen to assess the intensity of immunity in animals vaccinated against rabies. In the course of the study, we analyzed main immunochemical characteristics of antigenic fractions of the rabies virus isolated in a 15-50% step gradient of sucrose density and obtained by reprecipitation with a saturated solution of ammonium sulfate. It was found that the major fraction of the purified antigen is located in the region of 66.2 - 67 kDa; also, the isolated preparation is characterized by a minimum content of secondary proteins. As a result of determining the serological activity of antigenic fractions by the indirect ELISA method, their optimum concentrations for sorption on polystyrene plates were determined. A total of 90 sera of immunized cattle, small cattle and dogs selected in the regions of Tatarstan, Bashkortostan, and the Kirov Region of the Russian Federation were investigated. As a result of the study of sera in ELISA, the titers of post-vaccination antibodies corresponding to the range of 1.25-20 IU / ml were determined; in 97.7% of sera, the antibody level exceeded the recommended protective level (0.5 IU / ml). As a control test, we used a neutralization reaction on white mice; when comparing the results of RN and ELISA, a significant positive correlation was found. The obtained results testify to the high diagnostic efficiency of antigenic fractions and prospects of their use for the purpose of mass screening of the state of specific immunity in vaccinated animals.

Ureaplasma diversum is an opportunistic pathogen of cattle and its carriage is often asymptomatic. However, it provokes various respiratory and reproductive diseases, which reduce the fertility of cattle. The association of U. diversum carriage in the reproductive system of female cattle and abortions, stillbirth and the birth of weakened offspring was described previously. The purpose of this study was to assess the effect of U. diversum colonization of the vestibule of vagina in cattle on the effectiveness of their fertilization. For the study, smears from the surface of the mucosa form vestibule of vagina of 33 animals were examined. The presence of U. diversum in the samples was examined by real-time PCR. The frequency of U. diversum in the study group was 56.25%. There was a decrease in fertilization efficiency according to indicators such as the number of fertilization, which resulted in the pregnancy and the time interval between the calving and the pregnancy in the group of animals which are ureaplasma carriers. Five animals in the study group had symptoms of granular vulvovaginitis, and no other symptoms of the reproductive diseases were detected. The connection of granular vulvovaginitis with colonization of the vestibule of vagina by U. diversum has not been established. According to the obtained data , the carriage of U. diversum leads to a significant decrease in fertilization efficiency in cattle, and an increase of the economic burden on dairy cattle farms due to the grow in the cost of fertilization and the maintenance of cows.

It is known, that in the last years in some cities of Russian Federation (RF) were registered outbreaks of natural focal and particularly dangerous infections. In these cases the source of the causative agents of the infections were domestic animals (pets) and synanthropic animals, that inhabit near human dwellings, on the territory of household and production objects and on the territories of the cities. Often increase in the number of domestic animals (including homeless and stray animals) conduces to worsening of epizootic situation on many infectious diseases, contributes to spread not only social, but also epizootic significant diseases. So, the dominant role of canine parvovirus enteritis, pestis carnivorum and parasitic blood diseases in the formation of contagious pathology of domestic animals on the urban territories was noted by many researchers. Skin diseases have significant share, in particular - dermatophytosis and ectoparasitosis. In connection with it, the main goal of our research was: to study role and place of some diseases in formation of nosological profile of the contagious pathology certain types of animals in conditions of the region. The objects of researches were: domestic, wild and agricultural animals and also the materials of expert estimations of epizootic situation on infectious and invasive diseases of these types of animals in Nizhniy Novgorod region. In the work we used public methods, such as the complex epizootological approach, the last includes the modern methods of epizootological diagnostic, elements of prognostic and statistical analysis. This paper presents a comparative analysis of the epizootic situation in the studied region, in particular in its individual administrative districts. This information must be taken into consideration in correction (improvement) system of antiepizootic measures for the some diseases in the specific conditions of place and time.

For a long time to receive vaccines, a vast experience has been accumulated in the manufacture of inactivated vaccines, namely, the growth of the virus. We set the task to determine the optimal parameters for obtaining a high level of the virus of the Newcastle disease (ND). Infection of embryos was carried out by infection in the allantoic cavity with a matte virus at doses of 10,000, 100,000, and others. Infected embryos were cultured and harvested after 72 hours, 96 hours, 120 hours. The selected material was studied for infectious, haemagglutinating activity and immunogenicity in an inactivated vaccine. Infectious, hemagglutinating and antigenic activity of the virus, is directly dependent on the time of cultivation regardless of the dose of infection. The greatest amount of the virus antigen of NB accumulates when infecting 200 million EID50 embryos and collecting the virus through 120 hours of cultivation.

When viral material is produced for the manufacture of vaccines, manufacturers use the regulations for obtaining a viral material for live vaccines and focusing mainly on infectious activity. The research task was to determine the optimal parameters for obtaining a large amount of the IBK virus on commercial embryos that included the dose of infection and the time of collection of the viral material. The most immunogens were vaccine samples prepared from a viral antigen collected for 120 hours of virus culture, and the infectious activity of this sample was lower than that of samples taken at 72 and 96 hours of culture. The greatest amount of viral antigen IBK accumulates when infecting embryos in a dose of 100 000 -200 000 EID50 and collection of the virus through 120 hours of cultivation.

Marek's disease, Newcastle disease, infectious bronchitis of chickens, infectious bursal disease, egg production syndrome, reovirus and metapneumovirus infections dominate in the nosological profile of viral poultry diseases. In the scheme of prevention of viral diseases of birds, special attention is paid to these diseases. The effectiveness of specific protection of birds depends on the timing of the planned vaccination, which in turn depends on the multiplicity and level of maternal antibodies in chickens at the time of immunization. A more effective immunization is considered the use of vaccines in the presence of low and uniform levels of maternal antibodies in poultry farmers. The proposed scheme for vaccination of poultry contributes to the formation of intense immunity, reducing labor costs for immunization and reducing stress in the population.

Nizhniy Novgorod region remains an unfavorable territory for rabies for many years. The functioning of this disease as a parasitic system occurs with participation of wild, domestic and agricultural animals, and also human. In connection with it, we set a goal: to study particularities of epizootic manifestation of this infection and, in particular, the extent of spread and endemicity (enzooticity). In the work we used the complex epizootological approach; the last includes the modern methods of epizootological diagnostic of animals’ diseases. The objects of the research were: unfavorable area and epizootic pocket of rabies infection in Nizhniy Novgorod region, and also domestic animals and wild carnivores (flesh-eating animals). In this article we represented comparative analysis of epizootic situation for rabies in Nizhniy Novgorod region for 2001-2017 years, and also for the first half-year 2018 year. During our research it was installed, that in Nizhniy Novgorod region rabies is characterized by pronounced territorial and population limits, with expressed tendency to expansion of the limits. So, in 2011 was noted 34 facts, in 2012 - 35 facts, in 2013 - 61 facts, in 2014 - 62 facts, in 2015 - 61 facts, in 2016 - 36 facts, in 2017 - 42 facts, and for the first 9 months of 2018 - 41 facts of rabies. We installed, that infection of rabies is territorial timed to some districts of the region, where 64.1% of the total number of reported cases occur in foxes; the last confirms the data about original incipience of rabies into the wild nature, with the vector of subsequent dissemination.

In the Northern-East agricultural climate of Nizhny Novgorod region there are 45 potentially threatening infectious and invasive parasitic system, 41 of which (91,1%) have been confirmed by direct and indirect screening methods of biological material taken from animals and their habitats. Farm animals and pets are involved in the functioning and epizootic manifestation of infectious and parasitic systems in the region. In 70,7% of all cases the epizootic manifestation of parasitic systems involved only one certain type of animals; 29,3% cases involved 2 - 5 different types of animals, which means that parasitic systems function on the polyhostal basis.

The problem of deratization at veterinary surveillance facilities, including husbandry buildings, where most of rats and mice are concentrated, is very topical, because rodents are carriers of more than 200 different infectious and invasive diseases that are common at people and animals. Nowadays rodenticides were excluded from the group of medicines, which circulation is regulated by the state, in accordance with 61-FL «About the circulation of medical products», and sometimes results of research of rodenticides, offering for application in veterinary practice, do not have all necessary data proving their biological effectiveness and safety. Considering that rodenticides are highly toxic poisons not only for rodents but very dangerous for other warm-blooded species, including human, the main condition for its using is prevention of possible toxic effect on people, animals and environment. To ensure the unity of requirements and the comparability of the results requires a certain order of scientific research with using modern standardized methods and criteria for a comprehensive assessment of biological effectiveness and safety of rodenticides, which are used on objects of veterinary surveillance.

Currently, most pathogens of respiratory diseases have a wide variability in the genetic structure and are represented by a wide variety of genetic types. Bovine viral diarrhea virus (BVDV) has the greatest genetic variability among pathogens of cattle respiratory infections. BVDV is divided into 2 genotypes recognized as independent species: BVDV 1 (20 subtypes, la -1t) and BVDV 2 (5 subtypes, 2a-2e), part of the isolates, called HOBI-like viruses, were attributed to the third type - BVDV 3. In order to effectively control bovine viral diarrhea, it is necessary to have information about the virus subtypes that circulate in the region, as well as the dynamics of the spread of the pathogen. Our previous studies confirmed the circulation of infectious BVDV among the breeding stock, intrauterine transmission of the virus to the fetus and the presence of virus carriers in farms in the Ural region. BVDV isolates from 6 samples of biological material from infected animals were isolated, the creation of a base of BVDV field isolates for subsequent genotyping and studying their biological characteristics continues. For further studies, we selected specific primers. The complementarity and specificity of the selected primers were evaluated by comparing with the base of the NCBI nucleotide sequences using the BLAST algorithm for searching for related sequences. The homology of the selected primers with sequences of strains and isolates of cattle viral diarrhea virus has been established.

We are offering the mathematic nornmetric point system for evaluation pathological process with dyspepsia of the calves. The evaluation system was tested in terms of scientific and practical experience on a limited population of young cattle (n = 40), their the age is 1-5 days. It's showed that in calves with a total score of 11-12 points (relatively healthy), the qualitative characteristics of the feces correspond to the normal physiological state: the consistency is pasty, the color is light brown, inclusions and pathological odor are absent. Representatives of Lactobacillus, Bifidobacterium, E. coli (99.09%) dominate in the microbial landscape of the large intestine. The total amount of pathogenic microorganisms (Staphilococcus, Enterococcus, Streptococcus) is less than 1%. In calves (7.5%) with a total score of 8-10 points, the quality indicators of feces had minimal changes. The relative amount of Lactobacillus, Bifidobacterium, E. coli was 81.4% of the total number of microorganisms. The number of Staphilococcus, Enterococcus increased to 103 CFU / g. Growth of Streptococcus, Proteus, hemolytic E. Coli to 8.5% is noted. In calves with acute intestinal disorders (total score 5-7 points), significant changes in the quality indicators of feces were noted: liquid consistency, color changes to yellow, putrid odor, inclusions in the form of mucus, blood or gas bubbles. The relative number of normal flora decreased to 66.57% (Lactobacillus, Bifidobacterium, E. coli). The growth of pathogenic microflora continued to increase: Staphilococcus, Enterococcus, Streptococcus - up to 103 CFU / g; hemolytic E. coli - up to 109 CFU / g. In the antigen composition of the pathogens identified the rotavirus and the coronavirus.

The article presents data on the analysis of the spread of bovine respiratory disease. It was found that the main age group of animals with bovine respiratory disease were calves aged from 5-7 days to 4 months. In 19% of cases pathogens of bovine respiratory diseases were diagnosed in calves: BPIV-3 in 9.8% of calves; BHV-1 - in 6.1%; BVDV - in 3.1%. Respiratory diseases in calves are caused by polyethological factors and proceeded according to the type of parasitocenosis in most cases was determined. In calves with combined lesions of the respiratory and gastrointestinal tract, 49.4% of the cases failed to identify the causative agents of intestinal infections, and in 50.6% - the following pathogens and their combinations were detected: BCoV in 21% of cases, BRV in 14, 8%, E. coli K 99 - 6.2%, E. coli K 99 + BRV - 4.9%, E. coli K 99 + BCoV - 2.5%, BRV + BCoV - 1, 2%. Eimeria bovis oocysts in 66.7% of the bioassay were found. Thus, in the event of respiratory and respiratory-intestinal diseases in calves, it is necessary to carry out a timely comprehensive diagnosis in order to identify the spectrum of agents of bovine respiratory diseases and intestinal infections. Determination of the combination of etiological agents involved in the pathogenesis of these diseases has a direct impact on the effectiveness of antiepizootic and therapeutic-prophylactic measures.

Currently, technologies based on the identification of infected and sick animals, followed by their isolation and culling, are being used to improve the livestock population from the bovine leukemia virus. The effectiveness of measures to eliminate leukemia in different animal populations depends on a large number of external and internal factors, ranging from the type of virus and breed of cows to the technology of their housing and environmental conditions. The inhibition of the defense mechanisms of animals, which occur in farms with contamination of agrocenoses with metallic and radionuclide pollutants, significantly affects the dynamics of recovery of these populations from the bovine leukemia virus. We carried out a retrospective comparative analysis of the degree of contamination of agrocenoses in the region with man-made pollutants and the incidence of leukemia in cows over twenty years of dynamics, and also studied the current state of agrarian biocenoses and leukemia status of cows in areas with varying degrees of environmental pollution with heavy metals and radionuclides. In the majority of enterprises located in areas with pronounced technogenic contamination of agrocenoses, high epizootic intensity of VL cattle infection was noted, which subsequently affected the intensity and effectiveness of health measures.

The bovine leukemia virus is widespread in the Russian Federation, in this connection in many regions of the Russian Federation was planned health antileukemic programs have been introduced. The success of measures for the recovery of disadvantaged farms from infection induced by BLV is largely determined by the specificity, sensitivity and practicality of diagnostic methods and their integrated application. We conducted additional serological tests of blood serums from young cattle of a healthy leukemia farm using the ELISA method. The screening revealed an additional 7.7% of animal virus carriers. The available data indicate the priority of the use of the ELISA method at the final stages of recovery in conjunction with the AGID for a reliable determination of the status of the herd in relation to BLV, including among young animals.

Currently, the main methodical method of specific prevention and control of acute respiratory viral infections (ARI) in cattle is vaccination. The aim of the studies was to carry out serological monitoring of the intensity of postvaccinal immunity to pathogens of ARI in cattle populations in agricultural organizations of the Urals region for the period 2015-2017. Serum from cattle of different physiological groups from 26 farms (n = 3044) was tested in indirect hemagglutination assay (IHA) and hemagglutination inhibition assay (HAI). Samples from farms in which the "Kombovac" and "Hiprabovis-4" vaccines were used. In 2015, 15.4% of farms reported nonobservance of vaccination plans, such as omissions of the next injection of vaccine; absence of vaccination coverage for all age groups; variation of the intervals between vaccination and revaccination; variation in the doses and methods of vaccine inoculation. In 2016, the number of such farms increased to 19.2%, in 2017 - to 30.8%. In a comparative analysis of the results of serology, it was found that in animals in farms without nonobservance of vaccination plans, a high titer of post-vaccinating antibodies to BHV-1, BVDV and BPIV-3 was detected in 96.1-97.5% of calves and in 98.7-100% of adults cattle. In case nonobservance of vaccination plans against ARI in cattle, the "protection index" of the population in the surveyed farms as a whole is reduced to 87.5-88.0%. Preserve epizootic well-being in relation to ARI, control epizootic process and limit dissemination of field strains of pathogens possible only with the formation of persistent protective population immunity, which is possible only with constant attention and planned methodical work.

The paper presents the results of studies of antibiotic resistance of microorganisms detected by PCR in milk shelter. When conducting research in 88,9% of samples, specific microbial DNA regions were found: Staphylococcus spp., E. coli, S. aureus, S. agalactiae. Microorganisms were represented both in the form of monocultures and in the form of associations. The presence of antibiotic resistance genes was found in 38,7% of pathogenic and conditionally pathogenic microorganisms. The mecA gene (Staphylococcus aureus resistance to 2 generation cephalosporins) was found in 32,4% of bacterial agents. ErmB gene (resistance of Staphylococcus spp. and Streptococcus spp. to macrolides of the 1st generation was found in 22,8% of microorganisms. In 4,3% of E. coli, CTX-M mutation genes were detected in the genome. Cells of the Enterobacteriace bacteria to cephalosporins were found in the genome 1, 3 and 4 generations were detected in 85,1% of E.coli DNA.

During spontaneous oxyurosis of the bearded dragon, hemoglobin level and the number of red blood cells decreased by 48.3% and 51.1%, respectively, compared with the control. Leukocytosis was observed with a relative increase in the number of eosinophils, heterophiles and azurophils. An increase in the number of leukocytes with a corresponding leukogram, as well as a simultaneous decrease in the number of erythrocytes indicates the presence of inflammatory processes in the body of reptiles with oxyurosis. The inflammatory process in the first group of reptiles was recorded for 14 days after dewormirng, whereas in the second only for 7 days. Before the deworming, the number of leukocytes in invaded reptiles was 13.2 ± 0.5 G/l - 13.7 ± 0.8 G/l, whereas in the control - 9.9 ± 0.6 G/l. In the first experimental group, the number of leukocytes was at a fairly high level up to 21 days of research, and in the second group only up to 7 days - 10.2 ± 0.4 G/l. In the leukogram of bearded dragon, eosinophilia was recorded in the first and second experimental groups, inclusive, by the 14th day of the studies. Heterophilia in the second group was up to 7 days of research - 19.1 ± 0.2%, and in the first - up to 14 days of research - 18.6 ± 0.4%. It should be noted that in the first experimental group, the number of azurophil in invasive bearded aga was 4.6 ± 0.3% - 3.1 ± 0.3% both before treatment and for 14 days, while in the second group their number was it was both before dewormirng, and on the 3rd day 4.5 ± 0.2%, and on the 7th day it significantly decreased to 2.9 ± 0.1% - reached the level of control. Thus, the use of the "Helmirept" already on the 14th day of research contributed to the normalization of morphological blood parameters, whereas with the use of albendazole, the indicators approached the norm by 21 days, that is, a longer recovery period.

The article presents the results of the commercial experiment on the testing of Monizen F orte drug (series 010618) with sheep estrosis. The work was carried out on 30 lambs of the North Caucasian breed, with a live weight of 25-30 kg and a high infestation by the larvae of nasopharyngeal gadfly (Oestrus ovis), which were divided into 2 experimental and one control groups (10 animals each). All animals of the experimental groups used the Monizen Forte drug in a dose of 1 ml per 20 kg of animal weight once individually intramuscularly (group 1 ) and orally with half the single norm of concentrated feed ( group 2). 14 days after the administration of Monizen Forte, at a dose of 1 ml per 20 kg of animal weight, a clinical examination of sheep from 2 experimental and one control groups was carried out, and it was found that in all sheep of 2 experimental groups the clinical signs of estrosis disappeared, while in the sheep of the control group, these clinical signs persisted. During the slaughter of 2 sheep from the 1^st experimental group and the opening of the nasal passages, the larvae of the nasopharyngeal gadfly (Oestrus ovis) were not found, which indicated the high effectiveness of the preparation.

The article reflects the results of testing a new complex composition "Fenazinal" in the form of boluses in dogs with dipylidiosis. In 2017-2018 in terms of sec. Herpegezh Kabardino-Balkaria were studied indicators of the effectiveness of the drug "Fenazinal" in the form of a bolus by the method of individual use of liver minced meat on 10 puppies heads 4-7 months. age invaded by imaginal stages of dipyllidia. Experimental and control puppies (n = 10) were divided into 2 groups according to the principle of analogues of 5 animals each. A prototype of a new complex anthelmintic composition “Fenazinal” was prepared in the form of boluses (5 gr.), Containing per 1g: azinox microparticles crushed to 15-30 micron size - 250 mg, albendazole - 150 mg, fenbendazole - 150 mg, bone flour - 100 mg, dry bentonite with a particle size of 15-30 microns -350 mg. It was established experimentally that in case of dogs dipylidiosis individually, once c “Fenazinal” in the form of boluses in a dose of 1 bolus per head showed extensibility (EE) 100% and intensity (IE) - 100% and recommended for implementation in veterinary practice as effective means of treatment and prevention of dogs dipylidiosis.

Leishmaniasis is a disease endemic to some southern regions of Russia and absent in the Volga region. However, due to the relative freedom of movement of animals and their owners, this pathology can appear in any part of the country, since it is unrealistic to control it because of the impossibility of testing each animal if it has no clinical signs. However, veterinary specialists should at least trace the path of the introduction of such pathology in a non-endemic region and try to predict its further spread. And also try to interrupt the propagation vector. Initially, such activities should be carried out in any veterinary clinic with the subsequent involvement of laboratories and conducting official expertise. Every suspicious clinical case of a disease that is not endemic for any region or geographical area requires careful study and analysis. After conducting such an analysis, veterinary specialists in the clinics can conduct primary studies of such an animal that will have a sufficient degree of accuracy and can make a presumptive diagnosis. For example, it is possible to carry out microscopy of the specimens obtained from such a patient and to detect in smears-prints - amastigotes, which are quite well distinguished under a conventional light microscope when stained according to Romanovsky-Giemsa and viewed *900. Based on the results of such studies, a primary diagnosis is made, followed by laboratory confirmation.

Nowadays specific place amongst parasitic systems is held by transmissible diseases of carnivorous. Still many aspects of epizootic onsets of dogs infectious diseases aren’t rather studied and unexplained. The purpose of our researches is studying pathogenesis of pyroplasmosis for further improvement of diagnostics, treatment and disease prevention among dogs in private sector of the city and the region.

Сaprolological studies of faecal samples from cattle (n=227) in 17% of adult animals and 6% of calves were identified Eimeria bovis oocysts. In cows with eimeriosis invasion clinical signs of the disease were not manifested. In calves with eimeriosis invasion clinical signs were recorded in the form of dyspepsia of varying severity in 60% of cases. Investigation of immuno-haematological parameters in animals with Eimeria bovis invasion revealed the following changes: anemia -hemoglobin reduced to 73.01±4.03 g/l, hematocrit reduced to 31.04±6.44%; leucocytosis - leukocytes increased to 15.30±2.16 X 109/l; shift of the leukocyte formula to the left by increasing the number of band forms neutrophils in 2.5-3 times; development of immunosuppressive state: decrease in phagocytic activity of cells of monocyte-macrophage group in 2 times, immunoregulatory index to 1.1±0.2 U; the level of circulating immune complexes in the blood serum -182.48±34.18 U. The results of the studies indicate a decrease in the overall resistance of the organism and the risk of developing autoimmune conditions in calves with Eimeria bovis invasion. When assessing the level of postvaccinal immunity against acute respiratory viral infections, it was found that the titres of antibodies against respiratory infections in calves with with Eimeria bovis invasion were 1.46-1.5 times lower than in animals without parasitic invasion: to BHV-1 -2.42±0,32 log2, to BVDV - 2,74±0,38 log2, to BPIV-3 - 7,52±0,17 log2.

In the regions of the North Caucasus, fasciolesis of ruminants is one of the dangerous biohelminthоsis and is distinguished by the intensity of invasion foci with high extensiveness of invasion, especially in adult sheep with fluctuations within 23-45% and II, 7-58 ekz./head. The goal is to test a new complex trematodocide composition “Chloxal powder 20%” during sheep fascioksis using the group deworming method. In terms of the farm “Dankan” of the Cherek district of Kabardino-Balkaria, 32 heads of ewes spontaneously infected with fascioksis were selected for the experiment, and they were divided into 4 groups of 8 heads in each group. Epizootological studies have established that, for the farm named, sheep fascioksis is an epizootically dangerous biological threat and occurs in an adult livestock with EI - 27 - 40% with II - 1 - 63 ekz./head. In ewes treated with fascioksis mixed with compound 1: 100, once a group method, a new complex trematodocide composition “Chloxal powder 20%” in a dose of 100 mg / kg body weight, for 15 days. after application, it has shown extensity and intensity 100% and is recommended as a means for group and individual deworming during chronic fascioksis the sheep.

The article presents an analysis of the level of somatic cells in the secret of the udder and the electrical conductivity of milk, on the basis of which the state of health of the mammary gland and the assessment of the incidence of cows with mastitis are studied. It was established that during the study period the number of healthy animals was 57.78-70.16%. Initial signs of subclinical mastitis were found in 13.23-21.80% of cows. Subclinical mastitis was diagnosed in 3.57-9.64% of animals. Clinical mastitis and complicated clinical mastitis were detected in 4.46-7.23% and 1.99-8.04% of cows, respectively. In 43.14% of cows there were single increases in the level of somatic cells. The maximum average number of somatic cells in the secret of the udder of cows in the herd was 440.31 thousand / ml, the minimum - 197.18 thousand / ml. The number of samples of the secretion of the mammary gland of cows with a high content of somatic cells was in the range of 12.44-21.43%. The electrical conductivity of milk in healthy animals was at the level of 3.5-4.5 1/Ohm*cm³. In animals with subclinical and clinical mastitis, the electrical conductivity of milk was 4.5-6.0 and 6.1-7.0 1/Ohm*cm³, respectively.

The problem of liver disease in cattle over the years has received close attention from researchers. This is due to the widespread pathology, the lack of effective methods of diagnosis, treatment and prevention; and, often, an unfavorable prognosis for a sick animal. This article presents an analysis of the main biochemical parameters of blood serum, indicating a malfunction of the liver, in first-calf cows in the early novitating period. The revealed changes in metabolic indices may indicate that already cows after the first calving have prerequisites for the development of hepatosis and impaired liver function.

Kidney disease among pets, including dogs, have enough common pathology and annually in many kennels dog of Russia. Diagnosis at nephrological patients, as well as determination of the severity of the inflammatory process, its nature, evaluating the effectiveness of the therapy is impossible without ascertaining the laboratory-clinical picture of the patient's urine and blood of the animal. When clinical examination of dogs with suspected chronic kidney failure has been found that the disease was manifested in the form of oligofagii varying degrees of symptoms from selectivity in choosing the feed supplied to anorexia. There was apathy and weakness forced supine position, rapid fatigability, with various physical loads, stiffness, and standing often noted bulging back. Sometimes the present phenomenon of vomiting. Increased body temperature, tachycardia, dyspnea, anemichnost mucous membranes. When laboratory urinalysis sick dogs marked proteinuria and lejkocitourija, as well as increasing the number of epithelial cells. In the study of blood of experimental animals was marked leucocytosis, increased erythrocyte sedimentation rate, neutrophilia with shift of the nucleus to the right, lowering the amount of hemoglobin. When the biochemical study of blood dogs noted increase in the number of total protein globulinova protein fraction, raise, raising urea, urea, residual nitrogen nitrogen and creatinine. Content in the blood serum of experimental dogs General biliru-Bina, alkaline phosphatase, alanine aminotransferase (Alat) and aspartataminotransferazy (Asat) before therapeutic measures were also promoted. Thus, clinical and laboratory studies have shown that in the body of dogs with signs of chronic renal-sufficiency not occur deep destructive changes, vozhdaemye resistance change in the clinical laboratory indicators in the urine and blood of animals. Laboratory urine and blood of dogs with signs of chronic renal failure to diagnose this pathology in the early stages of development, that facilitates the therapeutic and preventive measures.

The unexpected death of the bottlenose Dolphin occurred in one of the dolphinariums. Before his death, the animal was kept in water with an increased amount of free chlorine, which was the cause of exacerbation of the present chronic form of peptic ulcer and led to death. On clinical examination the animal was observed a total inhibition, Dolphin refused to comply with commands of the trainer, swam to the opposite edge of the enclosure, he had decreased appetite, has twice observed vomiting foam. When examining the mucous membranes of the oral cavity and conjunctiva, their anemia was noted. Feces had a bright green color ("hungry feces"), was well soluble in water," cloud " fell to the bottom of the pool. The double Dolphin was spotted dark brown (almost black) stool. After the death of the animal at the opening of the abdominal cavity was found cloudy bloody liquid in an amount many times exceeding the normal limits. When examining the internal organs, a strong agonal inversion of the intestines, venous stagnation in the mesentery of the intestine, in the wall of the stomach and small intestine was found. On the large curvature of the first part of the stomach was well expressed venous pattern. When opening the gastrointestinal tract found numerous ulceration in the stomach (four ulcers) and duodenum (three ulcers). One of ulcers of the stomach was perforated. The serous membrane of the wall of the stomach and duodenum in the areas of ulcers was thickened. In addition, the wall of the stomach and small intestine was thickened. In the wall of the small intestine, multiple hemorrhages of a spilled nature were found. The ducts of the pancreas were filled with the contents of the intestine green. According to the clinical study, autopsy, laboratory results, it was found that the cause of death of the Dolphin was an ulcer disease, exacerbation of which contributed to non-compliance with the rules of water chlorination and stress experienced.

The authors performed four series of experiments in adult mongrel dogs. They investigated the temperature reaction of tissues in the zone of implanting titanium internal plates of different type (those without holes and those with holes) with hydroxyapatite coating. Depending on the experiment series the bioactive coating was applied by the technique of microarc oxidation (MAO) or by that of high-frequency magnetron sputtering (HFMS). The temperature of tissues elevated within the first two weeks after implantation, and that did not depended on the type of the product and the way of applying the bioactive coating. After three weeks of the experiment the dynamics of temperature reaction depended on the implant type, and the way of applying the coating had no significant effect. Four weeks after implantation the values of the investigated measure normalized in all the series. The obtained data will be used when evaluating circulation features in tissues of the zones of implantation in the products being tested, and they will be taken into account when analyzing the results of histological investigation.

In cats, neoplasms of the eye and its adnexa of a different nature are quite rare pathologies, therefore each clinical case of such manifestations should be considered separately. Cats that have clinical signs that indicate the presence of such a pathology should be taken into account and subject to examination in accordance with the “gold standard” of examining groups of oncological patients and whose animals can be presumably assigned to these groups. These standard’s includes direct and reverse ophthalmoscopy, measurement of intraocular pressure, if necessary, cytology, histology of selected specimens, and x-ray examination of the patient. Melanoma of various parts of the organ of vision and its adnexal apparatus in cats is a rare disease, therefore for the period of retrospection in the three 3 years in our case there were only 2 animals with a definitive diagnosis of malignant melanoma based on studies conducted in the veterinary clinic. Both animals had old age, wrong diagnosis made in another clinic and ineffective therapeutic measures prescribed by the previous doctor. Since the reference ophthalmologic procedure is not conducted in all clinics, the quality of diagnosis in the case of this type of ocular neoplasms is rather low. Therefore, those who come to the reference ophthalmic reception of animal owners should focus on a complete ophthalmological examination of a animal in the case of senile age of the animal, the presence of visible tumors, and glaucoma in anamnesis, followed by cytological and X-ray examination, if necessary.

As an object of research, broiler chickens of the daily age of the cross “ROSS 308” in the amount of 40 pieces (n=40) were selected. “Multibacterin” is a biologically active preparation that isn’t genetically modified and doesn’t contain taste adapters. It is a living symbiotic culture of lactobacilli in an amount of at least 100 million microbial cells per ml of substance. Next, blood samples were taken four times with an interval of one week from three weeks of age. Blood sampling was performed from the axillary vein. The indicators were determined according to standard During the studies, the following data was obtained, for example, the number of red blood cells was 14.7% up to a higher level in the control group, and the number of leukocytes in the control group was 21.9% lower than the same indicator in the experience group. The hemoglobin amount in the control group is 17.9% lower on average in the experimental group. On average, a 22% decrease in leukocytes was observed in the control group, this fact may indicate the need for the body to expend cell reserves to fight pathogen microflora as when applying “Mutibakterin" this should be reduced. The values obtained during the experiment are located within the reference values. Such results were achieved due to the favorable effect of “Multibacterin” on the gastrointestinal tract of broiler chickens. Thus, we can conclude that this additive reduces the body's immune response to external stimuli and allows the individuals to fully grow and develop.

NPO “API-SAN” LLC has developed a domestic drug epimec, which is based on highly effective eprinomectin, which has a wide spectrum of antiparasitic action on the imaginal and larval phases of the development of nematodes of the gastrointestinal tract and lungs, as well as sarcoptoid mites, insects and gadfly larvae parasitic in farm animals. Eprinomectin is a macrolitic lactone and a synthetic derivative of avermectin, the producer of which is Streptomyces avermitilis actinomycete. In contrast to foreign ones, the domestic drug is based on the natural avermectin complex consisting of two components B1a (at least 90%) and B1b (not more than 10%), which are formed during the vital activity of this soil microorganism. The 90-day administration of eprimec into the stomach of white rats made it possible to objectively evaluate the effect of the drug on laboratory animals in conditions close to real as well as in a more rigid regime. In animals treated with eprymec at a dose of 600 pg / kg, i.e. higher than therapeutic, it was noted only an increase in DGP, which was accompanied by a slight inhibition of animals and an increase in the level of protein in blood serum. In groups of animals that received the drug in doses at the level of therapeutic (200 and 300 mg / kg), all indicators characterizing the functional state of various organs and systems were at the level of animals from the control and did not differ significantly from it. This allows us to conclude that this drug can be used for conducting clinical trials on animals and introduced into production. LD50 of the drug epimec leaves 8.3 ± 0.47 g / kg body weight. According to the classification of toxic substances according to GOST 12.1.007-76 eprimek low toxic compound (IV hazard class). On the minor risk of developing acute fatal poisoning with a drug under single injection conditions, it characterizes the magnitude of the variability of lethal doses. This drug may be recommended for clinical trials and industrial production.

The purpose of the study is to conduct a drug trial in laboratory animals - mice. We focused on identification of hematological and biochemical changes in blood parameters after administration of a clinical dose of the study drug. During the trial it has been found that these doses of the drug show no visible signs of intoxication. Animals are active, move a lot, and respond to external stimuli; no defecation disorder. During six days there were no signs of deviation or mice death. The trial involved hematological, immunological, and biochemical tests. Analyzing biochemical parameters, it may be concluded that the experimental dose of the drug has no hepatotoxic or nephrotoxic effect on mice of 20 g in weight. Following the results of tests for TSH, T3, T4, we can draw a preliminary conclusion about a suppressive action of the drug on the basal and thyroid glands. On application of the experimental dose of the drug, the immunoglobulin rate in the blood serum of test mice shows a considerable fall. A decrease in the rate of IgA and IgM is indicative of insufficient humoral and local immunity. Therefore we can state a suppressive action of the drug on the immune system.

Regularities of selective mobilization simpato-adrenal, seroto-nin - and gistaminergic the systems of an organism, morphological and bio-chemical profiles of blood, activity of enzymes of reamination and factors of a nonspecific rezistenost against the background of application of the biological products directed to prevention of a transport stress and realization of biore-source potential of the imported heifers to pressure ecological and technological a stress factors are disclosed. The intramuscular injection the transported animal of the medicines PS-7 and Prevention-N-S reduced concentration of catechola-mines in components of blood of animal 1st and 2nd skilled groups by 7,2-16,5% and 10,9-19,1% and a histamine for 1,3-4,3% and 2,6-4,1% in compari-son with control and, on the contrary, increased concentration of serotonin for 2,2-4,1% and 2,6-5,5% (Р<0,01-0,001). Against the background of application of biological products improvement of reproductive qualities of heifers of the 1st and 2nd skilled groups is established, the age of fruitful insemination for 1,35 and 1,53 months, age of the first childbirths - for 1,0 and 1,2 months, the index of insemination - in 1,42 and 1,93 times, service period - was reduced by 8,8 and 12,2 days and the breeding effeciency in 1 hunting in 1,7 and 2,0 times ( Р <0,05-0,01), than in control raised.

The wide spread of dyspepsia in calves against the background of chronic iodine deficiency has a combined negative impact on production performance in cattle breeding. Chemotherapeutic agents of different groups used in the treatment of dyspepsia are effective, but have a number of side effects that adversely affect the incidence in later periods of ontogenesis. Despite 100% recovery of animals with the use of enroflon and Ceftriaxone in the complex treatment of dyspepsia, relapse of the disease was registered in 75% of animals, and the incidence of bronchopneumonia in 1.5-2 months was 100%. In addition, the use of enroflon and Ceftriaxone without additional iodine subsidies in the diet causes inhibition of thyroid function and contributes to the progression of endemic goiter. In calves, treated as an etiotropic treatment of "Monclavite-1 " in dilution 1: 2 with water, to the thirtieth day the concentration of TSH is 30% lower, and SV. T4 is 15 % higher than in control animals, which indicates the euthyroid state of the thyroid gland, the effectiveness of treatment of dyspepsia is 100%. The use of "Monklavit-1" in production conditions is economically justified and recommended by us as a means of primary choice in the treatment of dyspepsia and prevention of iodine-deficiency conditions in calves living in the biogeochemical province for insufficient content of the element. Among the calves that received "Monklavit-1" is marked by the recurrence of dyspepsia 17% of animals, the incidence of bronchopneumonia after 1.5-2 months was 39%.

The effect of the new phytosorption complex on the morphobiochemical parameters of mink blood was studied. The herbal complexes and plant extracts that make up it increase the palatability of the feed, increase palatability, which in turn has a positive effect on the productivity of animals. To study the effect of the new phytosorption complex on the morphobiochemical and immunological parameters of young mink, two groups of minks of the standard dark brown color (Vyatka animal breeding, Kirov oblast) were selected, 20 animals each. Young animals at 40 days of age were deposited into cells of two individuals each. The experimental group, in addition to the total diet, was injected with a phytosorption complex at a dose of 2 g / goal. Animals of the control group received a common diet without additives. Asked the drug daily for 116 days.

The main goal of our work was to study the honey flora, which is of great importance for the development of beekeeping of the Republic of Dagestan, and the analysis of its bioecological structure. Methods In all the high-altitude zones of Dagestan, honey plants were collected in different seasons (spring, summer, autumn) during their flowering. The collection and processing of material was carried out according to the approved method. The species composition of honey plants was determined using determinants of famous scientists. Bioecological analysis was carried out according to well-known methods of domestic authors. Results. For the first time in the Republic of Dagestan, a bioecological analysis (systematic, biomorphic, phytocenotic, ecological) of the species composition of the honey-bearing flora was performed. Bioecological analysis of honey plants in a quantitative ratio reveals: a) a systematic list; b) the structure of woody and herbaceous life forms; c) geobotanical distribution of phytocenoses represented in different communities, which are determined by the geomorphological and climatic conditions of Dagestan; d) ecological groups in relation to moisture and their growth substrate. The paper discusses the impact of honey resources on the development of the beekeeping industry of Dagestan. Conclusion The results obtained make it possible to systematize the species diversity of the honey plants of Dagestan. We have identified 370 species of honey plants belonging to 31 families, 106 genera. Analysis of the obtained results allows us to conclude that certain families of honey plants are the most common and are of greater importance for the development of beekeeping. In spring, the species diversity is more widely represented than in other periods. In honey plants, the life form of perennial grasses prevails, in the phytocenoses the meadow element is more pronounced, the ecological group of mesophytes is more pronounced.

As part of the research work "development of methods for identification and identification of target genes and new regulatory sequences of genetically modified organisms" in the fgbi "VGNKI" proposed a new concept of laboratory control of raw materials, feed, grain and products of its processing containing genetically modified components. A research strategy based on the use of risk-based and matrix approaches to research has been developed. Their use increases the effectiveness of GMO detection (in 2014 the detection rate was 4 %, in 2015-2017 - an average of 35%), and also allows to identify unregistered genetically modified lines.

This paper is contained data on evaluation of the «Vigozin» in broiler chickens effect on veterinary-sanitary examination of the meat «Vigozin» is based on L-carnitin, it takes part in breaking up the excessive of fatty acids and plays a direct role in transport of acetyl-coenzyme A in mitochondrion. The object of the research is cross of broiler-chickens «TOBB-500», 5, 7, 12, 19, 28, 36 and 46-days old. In order to carry out this study four groups were formed - one control and three experimental groups, 2000 birds in each group. To evaluate veterinary-sanitary and safety parameters of the meat the organoleptical bacteriological and physicochemical analyses were carried out. At the age of 28 days daily weight gain of the birds was higher -37,8 g in the experimental group against 34,1 g in control group, also the mean daily weight 1099 g in the experimental group against 995,9 g in control group. At the age of 46 days daily weight gain of the birds was 46,26 g in the experimental group against 43,07 g in control group, also the mean daily weight 2166, 9±0,45 g in the experimental group against 2021,4±0,89 g in control group accordingly. The organoleptic, physico-chemical and bacteriological parameters and safety of the experimental group meat are not inferior to the same parameters of the control group meat; the experimental group meat is a good quality. The study data of experimental group poultry performance is signify favorable effect on mean daily weight gain of the poultry.

The purpose of the study is to study the effect of the new phytosorption complex and the drug Marimix 5: 0 on the growth and development of black-motley calves. The phytosorption complex contains as a formative substance a set of sorbents, which are the matrix for plant extracts, ensures their delivery to the animal's body. Marimix 5: 0 is a hydrolyzed mussel meat containing a complex of essential amino acids and microelements. For this purpose, 4 groups of animals were formed, 30 animals each. The first and second group was added phytosorption complex. The drug was administered at a dose of 1.5 g / kg. The preparation was prepared daily, dissolved in 1.5-2 l of warm water and set orally to the animals for 30 days. Additionally, the second group of calves was intramuscularly injected with the drug marimix 5: 0 at a dose of 0.2 ml / kg for 5 days. The third group was administered the drug marimix 5: 0 intramuscularly at a dose of 0.2 ml / kg for 5 days. The fourth group was the control and received a common diet, according to physiological norms, without the addition of drugs. Throughout the experiment, a daily clinical examination was performed, at the end of the experiment, the change in the body weight of the animal was evaluated. Studied the effect of the studied drugs on the morphobiochemical blood parameters of experimental animals.

The influence of non-infectious pathologies (cannibalism and cloacitis) and biochemical status of laying hens on egg quality was studied. The studies were conducted on hens of cross Highsex Brown. The content of total immunoglobulins in the blood serum of laying hens exceeds the normal limits (norm is 7-10), which indicates the absence of immunodeficiency and tension of the immune system, especially in clinically healthy poultry. The lysozyme level of all groups of laying hens is below the physiological limits of the norm (norm is 3.5 - 5). The glucose content in the blood serum of the studied groups was within the normal range. The ratio of the egg components in all groups was within normal limits. All the tested eggs do not meet the regulatory indicators for the level of controlled vitamins. However in the eggs of clinically healthy poultry vitamin A is higher than in the ones with cannibalism and cloacitis by 17% and 33% respectively. We also note the superiority of a healthy poultry against those suffering from canibalism by vitamin E, but all three groups do not meet the norm (the level of its content in the yolk should be 25-40 gg/g). Vitamin B2 level in all groups exceeds the norm (2-3 μg/g), and the level of carotenoids of all groups is below the norm (18-20 μg/g). We believe that the imbalance of vitamins in the yolk is a consequence of the clinical condition of the poultry, as well as insufficient content of the relevant components in the diet of the poultry. When selecting eggs for incubation it is recommended to exclude the possibility of getting the eggs from laying hens with non-infectious pathology of cannibalism and cloacitis into the incubator.

The priority of nutritional research is related to the growth of animal genetic potential, the introduction of new technologies, the prospect and the need to increase the conversion of feed nutrients into products and the overall efficiency of the industry. Modern technologies of highly productive livestock production require the use of physiologically adequate and economically sound feeding systems and standardized feeding of animals. One of the main reasons for these requirements for feeding should be recognized very weak attention to the organization of the correct (normalized) feeding of highly productive animals.

The work on the analysis of patent documentation for growing tilapia under various conditions of detention and feeding was carried out. The work was carried out within the framework of project No. 236-16-GK “Production of organic food from fish (Tilapia, African catfish, etc.) grown on the basis of local ecologically clean feed in accordance with international standards.”

Regularities of formation of protective and adaptive functions of an organism of the import meat cattle in the conditions of the Nizhny Novgorod Region on morphological and biochemical blood profiles, to cellular and humoral factors of a nonspecific rezistent are disclosed. It is established that immunoprevention of an organism of bull-calves biological products of PS-6 and Prevention-N-E realizes their bioresource potential of meat efficiency. Against the background of use of medicines the prelethal mass of bull-calves increased by 15,4 and 22,0 kg, lethal weight - by 13,8 and 17,5 kg and the mass of pair ink - by 9,9 and 19,6 kg. The mass of pulp of bull-calves of the 1st and 2nd skilled groups was higher in comparison with control on 8,0 and 15,6 kg, fat - on 0,9 and 0,7 kg, than bones - on 1,3 and 2,4 kg respectively (Р<0,01). The big mass of carcasses of bull-calves of skilled groups has defined also high exits of the most valuable junctures -back chest, lumbar and coxofemoral, for 1,9 and 2,2%, for 0,2 and 0,3%, for 0,2 and 0,8% respectively, than in control. The largest content of pulp of the premium characterized carcasses of bull-calves of the 1st and 2nd skilled groups respectively on 3,2 and 5,7 kg in comparison with control. The high quality of beef on organoleptic, biochemical and spectrometer indicators is proved.

The article presents the results of studies to determine the effect of additives of vitamins Bc and H on the reproductive efficiency of sows, and the impact of brooders on the growth and safety of their animal yield. The object of research were 120 sows of the Belarusian large white breed, divided into four groups by 30 heads each. The pregnant and examined lactating (young) sows of the first (control) group received the basic ration of combined feed according to the recipes of the agricultural enterprise. They gave the young sows of the experimental groups the additive by 1 kg of dry matter feed over the first nine weeks of gestation in addition to the main ration: they gave the second group of sows 0.1 mg of Biotin; they gave the third group of sows 3.0 mg of folic acid; they gave the fourth group of sows 0.1 mg and 3.0 mg of vitamins H and B_c in the complex. After the sows’ farrowing, the experimental groups were divided into two subgroups each. The piglets of the first subgroups were kept under IKZK 220-250 infrared lamps or on heated floor during the entire suckling period. The source of heating piglets in the other subgroups were incandescent lamps with a capacity of 100 W or heated floor, and the means of heat localization from birth to weaning were cone-shaped brooders over the first two weeks of life. It is established that the introduction of Biotin additive increases the fertility of sows by 5.9 % (P<0.01), folic acid increases the fertility of sows by 8.7 % (P<0.001), vitamins H and Bc in the complex increase the fertility of sows - by 12.6 % (P<0.001) in comparison with the controlled group. The optimization of temperature conditions in the rest area of piglets of the second subgroups when applying the brooder, allows to increase the safety of young animals by 2.8-3.5 %, live weight at weaning by 7.8-9.1 % (p<0.05-0.01), milking capacity of sows - by 9.8-13.4 % (P<0.001), the mass of the nest at weaning - by 11.6-14.1 % (P<0.001) in comparison with those indices in the first subgroups.

The aim of the research is to study the nutritional value of rabbit meat when applying feed additives. The object of the study were the rabbits of the Californian breed, the males. The material for the study - the carcasses of clinically healthy animals, the slaughter of which was carried out at the age of 4 months. Two groups were created, in the experimental group a feed additive (Sel-Plex) was used before slaughter, in the control group granulated food was fed (according to the farm's prescription). Further, the biochemical analysis, the amount of essential amino acids in the protein composition of muscle tissue, the calorie content of meat and the slaughter qualities of rabbit carcasses were studied. The introduced feed additive Sel-Plex has a beneficial effect on the meat production of rabbits. This was reflected in the slaughter yield, which was significantly more than in the control group. The calorie content of meat in the experimental group was 151 kcal (612.0 kJ), with the energy value of meat 2.4%. The studied indices of the ratio of essential and non-essential amino acids corresponded to the physiological norms, only a small difference was made in the experimental group relative to the control group. It has been established by studies that the introduction of a feed additive (Sel-Plex) in the diet of Californian rabbits in the diet contributes to an increase in the level of metabolic processes in the body of rabbits, from which the rates of growth and development of young animals and in In the end, the economic feasibility of the introduction of meat rabbit.

The Volga-Vyatka region is safe for radioactive contamination, but due to the annual increase in organizations using man-made sources of ionizing radiation, the increase in radiation-hazardous objects, their physical aging, as well as systems, complexes and means of physical protection, it is necessary to constantly monitor the radiation situation of both the Volga-Vyatka region and other subjects of the Russian Federation. During the analysis of the radiation situation in the Volga-Vyatka region of the Russian Federation, the following conclusions were made, namely, in recent years, the indicators of the specific activity of artificial radionuclides in the soils of the Volga-Vyatka region remain at stable levels. Their content does not exceed the background values of radioactive contamination of the soil for the territories of the Russian Federation. Pollution of the atmosphere by technogenic radionuclides in the territory of the Russian Federation is now caused by the secondary arrival of radionuclides from the territories polluted in previous years and emissions of the enterprises of the nuclear fuel cycle. In General, the content of technogenic radionuclides on the territory of the Volga-Vyatka region does not exceed the values of permissible annual volume activities for the population. Regular monitoring of the radiation situation in the Volga-Vyatka region makes it possible to detect any changes in the levels of radioactive contamination of environmental objects in a timely manner and to take the necessary measures to protect the population from exposure to ionizing radiation.

This article is devoted to the study of subclinical deviations indicators in the health status of cattle, identifying their causal relationships with the level of discomfort of the animal organism with habitat, in order to optimize the system for managing the population health of productive animals in the southeastern zone of Nizhny Novgorod area. The aim of the work was to study the subclinical pathology indicators of productive animals, forming a complex of their total pathology, reducing the main epizootological parameter of the population - the level of animal’s population health. Based on the quantitative and qualitative measurement of animal homeostasis, significant deviations of specific indicators of their internal environment were identified, and on the basis of evidence-based epizootology and epizootological thinking, the consequences of these deviations are explained in the form of prediction of developing pathologies of individual organs and body systems of animals as a whole. The main causes and cause-effect relationships have been studied concerning the subclinical animals pathology as a result of the comfort disturbance of their organism with the environment. Conducted research was made forecasting the outcomes of subclinical pathology of productive animals, the development of secondary epizootological parameters of their population: the level of population reproduction, its economic utility and epidemic danger in the conditions of the southeast agroclimatic zone of the Nizhny Novgorod region. The research results formed the basis for the development and application of schematic models of significant quantitative deviations from the physiological norms of specific indicators of the homeostasis of healthy cows in the studied region and their subclinical pathologies developing on this background. A scheme-model of the main measures vectors has been developed for managing the population health of productive animals and ensuring biological safety in the studied region.

Complete feed can be made knowing the true content of substances in raw materials, so it is important to constantly and quickly monitor the quality of raw materials and the production of feed. Animal nutritionists not only take into account the level of total nitrogen and protein (protein), but also the amount of essential amino acids. It is necessary to choose food that complement each other in amino acid composition, or add synthetic amino acids to the diet in order to fully meet the body's need for all essential amino acids. The analysis of the data obtained revealed that 73.4% of the material studied does not correspond to the indicators declared by the manufacturers. The greatest discrepancy is found in the content of the amino acid methionine (91.1%). The inconsistency in the content of the amino acid lysine accounted for 68.6% of the total number of investigated samples.

The microbiocenosis of gastrointestinal tracts is an important aspect of immunologicals and metabolites processes in a organism newborn calve. We studied the influence of the probiotic and how the probiotic to affect on the microbiocenosis of the intestines and immune system of newborns calves in conditions of scientific and production experience. On the thirtieth day of the experiment, we observed a tendency towards the development of intestinal dysbiosis, as evidenced by changes in the microbial landscape of the microbiocenosis. The level of normal microflora concentration decreased: Lactobacillus - by 43%, Bifidobacterium - by 25%. The growth are of pathogenic microflora has been noted: Klebsiella up to 0.5 ± 0.1 lg CFU / g, yeast-like fungi up to 1.0 ± 0.1 lg CFU / g, mold fungi - Aspergillus up to 1.0 ± 0.02 lg CFU / g . The calves of the experimental group after 30 days of probiotic application, an increase in the number of beneficial microorganisms was 63% on average in the intestinal microflora compared to the background indices (Lactobacillus to 7.73 ± 0.85 cfu / g, Bifidobacterium to 9.75 ± 0, 62 cfu / g). When immunological studies of blood from animals of the control group were performed, suppression of the immune system was recorded: the immunoregulatory index at the lower limit of the physiological norm (1.48 ± 0.52 cu), the relative amount of T-CD4 + and T-CD8 + was 53.33 ± 6,13% and 41,33 ± 7,02%. In the experimental group, the absolute number of T and B lymphocytes was higher by an average of 17% (0.8 ± 0.05 and 3.28 ± 1.07 109 / L), the immunoregulatory index corresponded to the upper limit of the physiological norm, the T - CD4 + and T-CD8 + were higher by 10-15% compared to the control group. According to the results of the study, it is established that the microorganisms that make up the probiotic feed additive (Bacillus subtilis, Lactobacillus plantarum, Enterococcus faecium) have a positive effect on the development of the intestinal microbiocenosis and on the development of the calves' immune system in the postnatal period.

Breeding and breeding work with cattle in the Sverdlovsk region is at a high level. This is evidenced by the number of breeding organizations and the results of animal productivity. Thus, 46 breeding organizations function in the region, including 13 breeding factories and 33 breeding reproducers, which contain over 44.0 thousand heads of cows whose productivity is more than 8.0 thousand kg of milk. A sample of highly productive cows with productivity above 10.0 thousand kg of milk per lactation for a number of years in the leading breeding organizations of the Sverdlovsk region in the amount of 8658 heads showed that 2912 heads were assessed by origin using immuno-genetic expertise. These animals were distributed by frequency of alleles. The analysis shows that breeding specialists should not pay special attention to animals that have the I2D'E'3G'O 'allele in their genotype. These cows have the highest productivity and yield of nutrients. Animals with the B2G2O1Y2D'E'3Q 'allele have the highest milk fat content. The content of the mass fraction of fat in the milk of these cows reaches 3.99%, which is 0.05-0.08% higher than in animals of other groups. The concentration of protein in milk showed no significant difference between the groups. Animals with G2Y2E'3Q ', G2Y2D'E'3G'O'Q' and I2D'E'3G'O 'alleles have the lowest index in the sample - 2.3 lactation.

Ecotoxicological study of two fishery water reservoirs with high mineralization of water located in the Chelyabinsk region: Kurakli-Mayan, Mayan. The morphometric parameters of reservoirs have been clarified, the chemical composition and water quality have been studied by 33 indicators, and 8 heavy metals have been determined in the bottom sediments of Lake Kurakli-Mayan. The fact of organic pollution of reservoirs is established, as well as the excess of MPCs of reservoirs for the majority of microelements and heavy metals. The observed concentrations of elements in the composition of bottom sediments were close to the previously established values for the reservoirs of the Chelyabinsk region.

The basic principle of maintaining health and obtaining the highest economic indicators in the conditions of modern industrial livestock and poultry farming is full balanced feeding. But providing high-yielding animals with necessary substances only at the expense of feed is an impossible task. Introduction to the diet of feed additives containing vitamins, trace elements, amino acids, the action of which is aimed at eliminating the deficiency of these components in the feed and the body of animals, is one of the most important methods of solving this issue. Information about the positive effects of vitamin-amino acid feed supplements Mauervit on the process of hematopoiesis in laboratory animals - mice, rats and rabbits is presented in the article. The feed supplement to laboratory animals was given orally, on an empty stomach, after twelve hours of fasting. During the experiment, the clinical condition and the effect on hematological parameters were taken into account. Feed supplement Mauervit consists of a complex of vitamins and amino acids, normalizes metabolism, supplements vitamins and amino acids with hypovitaminosis, increases the productivity and safety of farm animals and poultry. The disappearance of basophilia, lymphocytosis and monocytopenia in animals of the experimental groups was noted. A significant improvement in hematological parameters in all laboratory animals is established. The amount of hemoglobin increased significantly: in guinea pigs by 13.6%, in white rats - by 4.67%, in rabbits - by 9.27%; and red blood cells in guinea pigs by 13.03%, in white rats - by 20.04%, in rabbits - by 24.14%.

The results of the application of fodder additive based on colloidal silicon dioxide for elementary dyspepsia in young cattle are given in the article. Reduction in the severity of clinical manifestations of the disease occurred on the third day and the recovery period was reduced by 5 days when feeding the feed additive in addition to the traditional treatment regimen. Analysis of blood hematologic parameters revealed a lower intensity of the level of inflammatory processes in calves receiving a feed additive. Before the experiment, an evaluation of the immunological parameters of the blood was carried out. Imbalance of immunocompetent cells of T- and B-systems of immunity was revealed. An increase in the number of lymphocytes in 1.4 times was noted after the application of colloidal silicon dioxide to calves. The relative number of T-lymphocytes and B-lymphocytes was 1.2 and 1.35 times higher, respectively, than in the background. By the end of the experiment, the level of phagocytic activity in the animals of the experimental group was 1.2 times higher in comparison with the control group and was 34% and 27%, respectively. The level of circulating immune complexes (CIC) was 1.6 times higher than the upper limit of the norm at the beginning of the experiment. By the end of the experiment, the content of the CIC reached the normative values only in the group receiving the feed additive, and amounted to 91.36 conventional units. An indirect effect on the calves living weight was positively affected by the immunological parameters of the blood of the animals in the experimental group. The increase in live weight in two, three and four months was higher in calves, who received fodder supplement at 21, 11 and 15%, respectively.

The article considers the influence of probiotic feed additive based on bacteria Bacillus subtilis on the restoration of the reproductive system of laying hens of the parent herd during the period of forced molting and in the second cycle of productivity. The main productive and biochemical parameters characterizing the recovery of laying hens after forced molting are analyzed. A decrease in the level of creatinine and phosphorus in the blood serum of chickens, an increase in the concentration of hormones thyroxine and triiodothyronine due to the use of probiotic supplements after fasting based on bacteria Bacillus subtilis in doses exceeding the recommended input. At the same time, the experimental groups recorded a decrease in the number of eggs contaminated and with damaged shells, against the background of an increase in the amount of vitamin A in the egg yolk. During the production tests it was found that the use of probiotic supplements based on Bacillus subtilis after fasting leads to a more rapid recovery of the body of chickens: live weight and egg production in the experimental groups was higher than in the control. With the calculation of economic efficiency, it was found that the conversion of feed and cost per unit of production in the experimental groups was respectively 2, 0% - 4.0% 0.3% -1.8% lower than in the control group. Rational introduction of a probiotic additive based on Bacillus subtilis is 0.3%, which is advisable to use during the entire period of poultry after molting, with the economic effect on 1 initial laying hen set 4.23 rubles, which is higher than in the control and other experimental groups.

Studies were conducted in tribal agricultural enterprises of the Sverdlovsk region. The object of the study is cattle of black and motley breed of the Ural type. Selection of cows-first-calves with a productivity of over 10,000 kg of milk was carried out. The yield of 274 animals is 10747 kg of milk with butterfat 3,80%, the protein content is 3,25%, the coefficient of milkness is 1895 kg and the amount of nutrients is 757,7 kg. The investigated sample of first-calves is ranked by the abundance of milk in rows from 10,0 to 14,0 thousand kg of milk. It was found that with an increase in the milk productivity of cows from 10433 kg to 13356 kg of milk (P< 0,001), the fat-milkiness of the first-calf significantly decreases from 3,81% to 3,77% (P< 0,001), respectively, protein milking rises from 3,25% to 3,37% (P<0,05). Analysis of the constitutional features of the exteriors of cows-heifers according to variational series proves, that with the increase in the milkiness of animals, the values of the measurements of the exteriors of the examined livestock are proportionally improved. The indicator «growth» varies from 8,4 points to 8,5 points, the depth of the trunk of the first pot is significantly increased by 0,9 points (P< 0,05). Just reliably improve stati: «strength of build» - 0,4 points; «milk forms» - 0,8 points; «length of the front parts of the udder» - 1,0 point; «depth of imputation» - 0,5 points; the severity of the central ligament is 0,1 points, (P< 0,001). The first-calf cows of the sample studied have a milky body type and correspond to the bonito complex «Elita Record» class. Thus, highly productive animals are necessary not only for obtaining a large amount of milk, they reflect the genetic potential of the breed and make it possible to obtain offspring that carry a valuable genetic resource.

The article touches upon the current issue of the risks of pathologies of the reproductive system of laying hens and roosters of the parent broiler herd. Describes the causes and effects influencing the decline in productive performance of breeding poultry, followed by the calculations of economic efficiency. The schemes of application of probiotic preparations based on bacteria Bacillus subtilis to reduce the harmful effects of alimentary, technological and veterinary factors, as well as contributing to a more complete disclosure of the genetic potential of poultry.

Correlation adaptometry (CA) - is a branch of Russian biology, medicine and bioinformatics. It studies the link formation in biological systems and their change under different extreme and stress factors. The theory and practice of CA states, that with the increase of adaptive costs of population in response to stressful influence, the weight of the correlation graph (WCG) rises. WCG is the summary of all the absolute values of the correlation coefficients. Using the Spearman’s correlation method 7 heavy metals (Mn, Fe, Co, Ni, Cu, Zn, Cd) in the muscle and bone tissue of the roach Rutilus rutilus (L., 1758) and perch Perca fluviatilis (L., 1758) from the two Ural lakes, containing different amount of mineralization, were analyzed and the amount of WCG was evaluated. The results were compared using the four-way ANOVA on pseudovalues of the jackknife. It was proven that in the water with high mineral content (TDS=4,57 g/l) the WCG was much, than in the fresh lake (TDS=0,48 g/l): F_(1/36)=13,0; Р=0,001. The conclusion is made that the data on microelemental contents of the organisms can be used in the CA methodology to gauge the levels of adaptive costs to sustain homeostasis and to estimate the levels of stress impact in ecological and veterinary research.

Historically, agriculture complexes in the Ural region are located near enterprises black and non-ferrous metallurgy. Moreover, the concentration of industrial facilities in this region is the largest in Russian federation. When are agriculture enterprises placing on industrial territories it leads to chronically influence an organism animal. Chemical, physical and another factors a significant change of animal health. With short-term exposure or low concentrations of man-made factors in the body, compensatory processes develop, so that there are no changes in clinical condition and productivity. Further deterioration of the environmental situation causes the development of immunosuppression, metabolic disorders, allergic conditions. An immuno-hematological study of cows 5-6 years old, calves of 30 days and 6 months of age was carried out. It has been established that the development of secondary immunodeficiency occurs at all stages of ontogenesis in industrial territories. Hemoglobin of cow’s levels decreased by 27.1 %, erythrocytes - by 17.9% compared with the average regional values, phagocytic activity was 48%, while the phagocytic index was 4.87. In calves of 30 days of age, the number of erythrocytes was lower by 15%, the hemoglobin content - by 12.3%, the number of T-lymphocytes by 1.8 times, and B-lymphocytes - by 2.3 times. By 6 months of age, the number of eosinophils and monocytes increases significantly in calves, which may be due to the antigenic load during vaccination. The adverse effect of environmental factors is accompanied by a reduction in humoral and stimulation of the cellular defense mechanisms of the body: inhibition of hematopoiesis, lymphocytopenia.

Organophosphate insecticides are actively used to fight ectoparasites in cattle and sheep. These preparations are made in large quantities and are actively distributed by wind and water. Therefore, the problem of organophosphate insecticide poisoning is currently very relevant. In clinical practice, there are often circulatory disorders, the appearance in the blood of conglomerates of erythrocytes in case of POI poisoning. We conducted a series of experiments to monitor the movement of blood in the vessels of a mezoappendix of rats under anesthesia. Phosphacol in various doses was used as a poisoning agent. Blood CE activity was determined by potentiometric titration using the Radiometr autotitrator. Studying the phosphacol effect on red blood cells based on in vitro experiments. Studies have been conducted to study blood circulation in the microvessels of the mesopendicular in rats. Phosphacol was used for poisoning at a dose close to twice that of LD99 intramuscularly. A model treatment and prophylactic antidote based on atropine 5 mg / kg and carboxime 5 mg / kg was used as an antidote. Further, we studied the effect of model therapeutic and prophylactic antidote on the deformation of erythrocytes. Under the obtained results, it can be concluded that at a FOS poisoning, a decrease in blood flow velocity, and red blood cell deformation occur, numerous conglomerates are formed. All these changes deteriorate the general condition of animals in case of organophosphate poisoning. It was found that the use of model antidote, based on atropine and carboxime, helps to reduce the number of modified erythrocytes. When using an antidote for therapeutic purposes, the number of modified red blood cells is 39.3 ± 0.5 **%. The use of an antidote for prophylactic purposes reduces the number of deformed erythrocytes to 39.1 ± 0.1 **%, compared with a group of rats poisoned with phosphacol, but not receiving antidote therapy. The combined application of atropine with carboxyme contributes to the normalization of the blood flow rate to the physiological norm of 158 ± 15 rpm.

Breast cancer - is a malignant neoplasm, proliferating from tubular epithelium and mammary gland parenchyma. Neoplasm proliferation is determined by complex interactions between organism systems, regulating the response to cells influenced by different oncogenes. There is no conventional data about breast cancer etiology. Breast cancer is the second widespread neoplasm (after skin tumors) in dogs and has third place between the most spread pathologies. Mammary glands are in constant process of proliferation/involution due to its physiology. Breast diseases are diagnosed in the complex. It includes; cytological, histopathological analyze, x-ray study, ultrasonography, CT and MRI. All these methods have pro- and contras: one has high specificity but needs time (histopathology), other - needed to find metastases are expensive (CT, MRI). All these lacks and absent of oncology disease serum markers drive to find new and cheap diagnostic methods for breast cancer detection. In this review, we analyzed available data about ceruloplasmin as a marker of neoplastic processes, in order to evaluate its utility as a diagnostic method for mammary gland cancer.

Genes of the depigmentation of the feathers of chickens "MoD" and "mo" (mottled are) allele in allelomorphic series MoD, Mo+ and mo. Incomplete dominant depigmentation gene " MoD " with penetrance in heterozygote Mod/Mo+ 40%, and in heterozygote MoD/mo 90% is in some breeds and lines in the latent state. White chickens homozygous MoD/MoD may suffer from a visual defect-blindness with exophthalmos. Their egg production is less than black-white australorps’ (143 ± 3.0 eggs) and heterozygotes MoD/mo (155 ±2.3 eggs). Gene "mo" should include in parents’ form of crosses, so it alloust to except negative gene "MoD" in the homozygote and increases productive hybrids.

The article describes the results of studies on the content of total protein, urea and creatinine in the blood serum of female sheep and pigs in postnatal ontogenesis, living in the area of iodocyte. As a result of researches it is established that reliable distinctions on level of the General protein in blood serum of sheep are revealed between 9 and 12-month animals, at 12-month females it was lower on 5%. The analysis of data on the level of total protein in the blood of pigs revealed significant differences in the parameters of this indicator between the previous and subsequent groups. Its lowest values are recorded in newborn animals - 47,5±4,15 g/l. In the study of urea content, significant differences were found in sheep between newborns and 3-month, and 9 and 12-month, and in pigs - in 3 and 6-month age. The level of creatinine in sheep significantly changed only at 6 months of age, which is 8.3% (p≤0.05) lower compared to 3-month-old lambs. In pigs, the value of this indicator in the sixth month of life was higher by 39.5% (p≤0.05), compared with the previous age period. Also in pigs there was a significant decrease in creatinine level in 12 months, compared with 9 months by 45.7% (p≤0.05). Thus, the data obtained can be used as a constant for sheep and pigs bred in the area of iodine deficiency, which is the Stavropol territory.

The paper presents data on age-related changes in the concentration of protein and steroid hormones in the blood of working dogs, depending on physical and psycho-emotional stress. It has been established that body temperature, respiration and pulse rates in young animals at the age of one and three years increase during the period of training. After a five-minute rest in year-old dogs, the pulse rate is above the norm by 20.17% and is 135.56 ± 2.50 beats per minute, the respiration rate is 80.85% and is 175.46 ± 2.51 respiratory movements per minute, body temperature is 40.02 ± 0.52 ° С, that is, 5% higher than in the state of rest. With increasing rest time, all physiological indicators of young dogs are close to their original position, a 60-minute rest after training for one-year-old and three-year-old dogs is not enough to restore the body's physiological parameters. While for adult dogs (five-year-old and eight-year-olds), a 60-minute rest after training completely ensures the restoration of general physiological parameters to a state of rest. The dynamics of recovery of general physiological parameters depending on physical and psychoemotional stress, taking into account the age of dogs, is accompanied by quantitative changes in the blood of hormone parameters: thyroxine, triiodothyronine, cortisol and thyreotrophin. It was established that the concentration of thyroid-stimulating hormone increases with age in dogs and is 1.153 ± 0.086 mIU / l in one-year-olds, and 1.471 ± 0.131 mIU / l in eight-year-olds, while the physical and psycho-emotional stress of dogs on the concentration of thyreotropin in the blood does not significantly affect. The hormone thyroxin increases with age in dogs, the concentration in one-year-old dogs alone is 27.32 ± 1.23 nmol / l, and in 8-year-old dogs it is 18.15 ± 0.45 nmol / l. The concentration of thyroxin in the blood of dogs increases during training, which seems to be connected with a large expenditure of energy. A 5-minute rest after training in blood of one-year-old dogs thyroxin is 34.70 ± 1.34 nmol / l, while eight-year-old dogs have a significantly lower blood concentration of 22.32 ± 0.38 nmol / l. At the same time, a 24-hour rest of dogs after physical and psychoemotional stress is sufficient to reduce the concentration of thyroxin in the blood to its original state. The highest concentration of cortisol in the blood of one-year-old and three-year-old dogs, the lowest in eight-year-old dogs. Cortisol in blood decreases with age in dogs and is 278.30 ± 15.30 nmol / l in one-year-old dogs, 184.60 ± 8.75 nmol / l in eight-year-old dogs. During the period of training, cortisol in the blood of dogs rises sharply and amounts to 333.91 ± 19.50 nmol / l in yearling dogs and 217.83 ± 6.20 nmol / l in eight-year-old dogs. The daily rest of service dogs after training is not enough to restore cortisol levels in one-year-old dogs, while in eight-year-old dogs the concentration of cortisol is at the initial level. In conclusion, it should be noted that the general physiological indicators of the body of working dogs and their hormonal status change with age and depend on physical and psycho-emotional stress. Daily rest is not sufficient to fully restore the physiological state of young dogs, while for adults the 24-hour rest is sufficient to restore the physiological state, they can be used to perform official duties.

The article presents data on the characteristics of the biochemical profile in cows with inflammatory diseases of the udder. The study of biochemical blood parameters in highly productive cows with the inflammation of the mammary gland showed an increase in the average content of total protein to 84,6±0.9 g/l, the increase in the number of globulins more than 45,0 g/l was observed in 76.9% of the cows. Also diagnosed with increase in the level of triglycerides in 73,1% of the animals. The increase in cholesterol over 5.0 mmol/l was observed in 19.2% of the cows. The average value of potassium concentration was 2.4±0.3 mmol/l, which is 1.7 times below the physiological norm. 16.3 per cent of the animals showed a decrease in sodium concentration below 130 mmol/l showed a reduction in concentration of bicarbonate less than 21 mmol/l at 9.1%, chloride less than 96 mmol/l in 18.2% of cows, respectively. The average content of zinc in the blood amounted to 20.9±1.2 pmol/l, while in 18.2% of the cows this figure was below the physiological norm. From 50,0% of the animals in the blood diagnosed by the reduction of magnesium less than 0.7 mmol/L. Have for 90.9% of the studied animals have been discovered increasing the concentration of copper in the blood, while the average copper concentration of 25.7±1.1 pmol/l, which is 1.4 times above the linguistic standards. The amount of calcium and phosphorus were within the physiological norm and amounted to an average of 2.1±0.1 mmol/l and 1.5±0.1 mmol/l, respectively, a slight deviation to the downside of these parameters was observed in 18.2% and 36.4% of the animals.

The course "Organization of Veterinary" in 1965 was transferred to the department of agricultural economics to improve economic education. The academic discipline was called "Organization and Economics of Veterinary". For 50 years of teaching the organization of veterinary affairs, the Academy has accumulated a wealth of experience in pedagogical, methodical, educational, scientific work.

November 15, 2018 marks the 100th anniversary of the birth of Urban Valery Valeriy Petrovich, Doctor of Veterinary Sciences, Professor and Head (1970-1999) Department of Epizootology of the St. Petersburg State Academy of Veterinary Medicine (1970-1999). Urban V.P. is an academician of the Academy of Agricultural Sciences / RAAS (1978), Honored Scientist of the Russian Federation, Honorary Professor of the Vyatka Agricultural Academy and the Vitebsk Agricultural Academy, Honorary President of the International Organization of Epizootologists of the CMEA countries, Academician of the Petrovsky Academy of Sciences and Arts (PANI).